MRC LMB Seminar Series

LMB Seminar: Molecular mechanisms that regulate the first cell fate decisions in human development - In Person Only

Kathy Niakan.

In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Monday 14 October 2024, 11:00-12:00

MRC LMB Seminar Series

CANCELLED - LMB Seminar: RNA Meets DNA: Dangerous Liaisons in the Genome

Karlene Cimprich - Stanford University School of Medicine, Department of Biochemistry.

CANCELLED.

Thursday 03 October 2024, 10:30-11:30

MRC LMB Seminar Series

Francis Crick Lecture 2024: Neuronal circuits for body movements - In Person Only

Silvia Arber.

In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Monday 30 September 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Feedback control of mitosis in the context of the kinetochore

Andrea Musacchio, Director, Department of Mechanistic Cell Biology, Max-Planck-Institute of Molecular Physiology.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96608781341?pwd=MG5QMXVmOStXcFVtalBqUlBYc0tEdz09.

Monday 23 September 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Linking nanoscale synapse organization, function and plasticity

Dr Daniel Choquet - University of Bordeux Institute for Interdisciplinary Neuroscience and the Bordeaux Imaging Center.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link:https://mrc-lmb-cam-ac-uk.zoom.us/j/94686992877?pwd=Q0VlRmFsRXNta0ZJMVhlRnZqNEs3QT09.

Monday 16 September 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Laser phase plate in cryo-EM and cryo-ET

Holger Müller.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99208619370?pwd=MkR4anNjVFhtbHlIQmRSZzBobWxNdz09.

Monday 09 September 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Separate yet connected: mitochondrial and nuclear genome stability

Agnel Sfeir.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link:https://mrc-lmb-cam-ac-uk.zoom.us/j/91614790739?pwd=QncrTFFvNG1xWVZJOWhqL0lTcHVIQT09.

Monday 01 July 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Mechanosensing in cancer invasion and metastasis

Laura M Machesky, Sir William Dunn Professor of Biochemistry, University of Cambridge.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99537530757?pwd=UVk1YjIyeFY4QzNjNkhwa0xwbERoQT09.

Monday 17 June 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Identification of alternative pathways for metabolism or cell death using haploid genetics

Thijn Brummelkamp, Netherlands Cancer Institute/Oncode Institute.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link:https://mrc-lmb-cam-ac-uk.zoom.us/j/95178919042?pwd=OUp6RUN3a0dkNFZqWGxQV0p0T0JOZz09.

Monday 03 June 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Evading ageing: Mitochondrial and proteostatic adaptations in oocytes

Elvan Boke, Group Leader, Centre for Genomic Regulation (CRG), Barcelona, Spain .

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/92134536179?pwd=bHVnRkpmamhnWWY2bXpVMHAyblhlZz09.

Tuesday 07 May 2024, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: Super-resolution imaging of transcription in living cells

Ibrahim Cissé, Department of Biological Physics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99208619370?pwd=MkR4anNjVFhtbHlIQmRSZzBobWxNdz09.

Thursday 11 April 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Biosynthesis and degradation of the underappreciated green polymer cyanophycin

Martin Schmeing, Ph.D., James McGill Professor, Department of Biochemistry and Directeur, Centre de recherche en biologie structurale, McGill University.

In person in the LMB's Klug Seminar Room (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96568201418?pwd=c3F0aCtOeTVwR3IyQzZYdkxoWHdPUT09.

Thursday 04 April 2024, 11:00-12:00

MRC LMB Seminar Series

CANCELLED: LMB Seminar: New therapeutic modalities based on pseudo-natural peptides, products, and neobiologics

Prof. Hiroaki Suga, Ph.D, The University of Tokyo, Graduate School of Science, Department of Chemistry.

N/A.

Monday 26 February 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Cell volume and dry mass across time scales in cultured mammalian cells: from milliseconds in migrating and circulating cells to homeostasis during cycles of growth and division

Matthieu Piel, Institut Curie.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96572384351?pwd=MkJzbE1qM2dGd0ZSTi9hTmV0elZ5dz09 .

Monday 05 February 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: The allosteric landscape of a protein

Ben Lehner FRS FMedSci, Head of Generative and Synthetic Genomics, Wellcome Sanger Institute, Cambridge, UK, ICREA Professor, Systems and Synthetic Biology, CRG, Barcelona, ES.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96896374524?pwd=VFJYbkZmRlZQREJ6a1QwelRSdEZwdz09.

Monday 29 January 2024, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: From regeneration to homeostasis: tissue-scale decision making

Pros. Prisca Liberali.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/97161414783?pwd=UEhEZUdDSVVLbDU0Q2lPdFhPQ3M2UT09.

Monday 15 January 2024, 11:00-12:00

MRC LMB Seminar Series

*CANCELLED* LMB Seminar: Alpha-Synuclein and its aggregation in neurodegenerative diseases

Prof Maria Grazia Spillantini, Professor of Molecular Neurology, University of Cambridge.

N/A.

Monday 11 December 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Power to the protein: analyse, signal and protect with bacterial superglues

Professor Mark Howarth, University of Cambridge.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/95625236862?pwd=NGttT1d6ay9SWFRqUHMvRWNPdDhyZz09.

Monday 04 December 2023, 11:00-12:00

MRC LMB Seminar Series

Crick Lecture 2023: Innovating metagenomics to explore the strange world of archaeal extrachromosomal elements

Jill Banfield, University of California, Berkeley.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96751041497?pwd=SDgyU1NMdjFVdENscUZqams4Z1RWUT09 .

Monday 27 November 2023, 11:00-12:00

MRC LMB Seminar Series

Perutz Lecture 2023: Decoding the protein dance

Prof. Dr. Paola Picotti, Associate Professor for Molecular Systems Biology, Institute of Molecular Systems Biology, ETH Zurich.

In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Monday 20 November 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases

Jeffery W. Kelly, The Scripps Research Institute.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94698100541?pwd=L0RIZUcvY0dvYjhaRW5VU0pXNThKUT09.

Tuesday 07 November 2023, 11:00-12:00

MRC LMB Seminar Series

Kendrew Lecture 2023: Cryo-electron tomography or the power of seeing the whole picture

Wolfgang Baumeister, Max Planck Institute of Biochemistry, Germany.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/98196424925?pwd=a0V2Z1FOYU5UZFgreHp1ckQ4Z2UyUT09.

Monday 30 October 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Talking to cells: biomolecular ultrasound for imaging and control of cellular function in intact organisms

Mikhail G. Shapiro, Max Delbrück Professor, Caltech.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94069360553?pwd=djJlT09ZOTlENzNJVzRYVnp6WWVZQT09.

Tuesday 12 September 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Decoding the role of solute carriers in health and disease

Professor Simon Newstead.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94311710455?pwd=N05mNDk4ZXlDZWdUTzVnaHJTQzRWQT09.

Monday 10 July 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Single-molecule studies reveal the dynamics of replication origin licensing

Stephen P. Bell, MIT, Dept. of Biology and HHMI.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93130142776?pwd=dEhGKzFGTkw2RGI1enhVSGg0Vm1VZz09.

Monday 03 July 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: What do we know about (your) antibodies? Novel insights from novel techniques in mass spectrometry

Albert Heck, University of Utrecht, The Netherlands.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/92910980652?pwd=U2V6MGFOOU9kbmRnckNaU05HaXl4QT09.

Monday 19 June 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Blending Proteins: Democratising Access to Beautiful Molecular Landscapes

Brady Johnston.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93844733292?pwd=RGczZ0szUnVxVUJOb0U5c1AvbWdhdz09.

Monday 12 June 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Tissue genomics: High throughout tools for measuring and perturbing tissues

Fei Chen.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93095291087?pwd=NGRzTnRJb3M0YWxqOC8xQXVNUXBmQT09.

Monday 15 May 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: The Extraordinary Life and Legacy of Sir John C. Kendrew

Professor Paul Wassarman, Mount Sinai, New York.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91598384955?pwd=RnE5M0p4bjU3bS8vMjFldHFadE9OZz09.

Tuesday 09 May 2023, 16:00-17:00

MRC LMB Seminar Series

Milstein Lecture 2023: Understanding the Hox timer by Using mammalian Pseudo-Embryos

Denis Duboule, Collège de France, Paris France, Federal Institute of Technology (EPFL), Lausanne, Switzerland.

In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Thursday 26 January 2023, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar: Engineering a bacteria for lung therapy

Prof. Luis Serrano.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99349389275?pwd=ZHI3em1DQTA0VTlVLzkvUTN6ZGkxdz09.

Tuesday 17 January 2023, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

Tim Clausen, Research Institute of Molecular Pathology (IMP).

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

Thursday 08 December 2022, 10:00-11:00

MRC LMB Seminar Series

LMB Seminar: Mechanism and regulation P element transposition in Drosophila

Donald Rio, Professor of Biochemistry, Biophysics and Structural Biology, Dept. of Molecular and Cell Biology, University of California, Berkeley, USA.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94108711681?pwd=cXN4VGlQVHBZYkpMUVJ0SXV3emtaUT09.

Tuesday 29 November 2022, 16:00-17:00

MRC LMB Seminar Series

New Frontiers in PKA Signaling

Susan Taylor, Professor of Chemistry and Biochemistry and a Professor of Pharmacology at the University of California, San Diego.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99725572898?pwd=NG82MzVpQmczczAvdkZzN2lJNkt1UT09.

Wednesday 09 November 2022, 11:30-12:30

MRC LMB Seminar Series

Crick Lecture 2022: Neurobiology of Social and Sickness Behaviors

Catherine Dulac, Higgins Professor of Molecular and Cellular Biology, Lee and Ezpeleta Professor of Arts and Sciences, Howard Hughes Medical Institute Investigator, Department of Molecular and Cellular Biology, Harvard University.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91021060396?pwd=c1o1TWVTSTNHTWM1dW5lcm54cURKQT09.

Thursday 03 November 2022, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Cryo-ET reveals sarcomere structures at molecular resolution

Prof. Dr. Stefan Raunser, Director, Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96648790745?pwd=Tkx6OVpoY01ieTRMTFMzZ0QvWWR2UT09.

Tuesday 18 October 2022, 11:00-12:00

MRC LMB Seminar Series

Regulation of mRNA translation and decay

David Bartel, Professor of Biology, MIT, HHMI, and Whitehead Institute.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99553714360?pwd=bVRGN3o1a0dsazJIMnVIemlRbjltZz09.

Tuesday 27 September 2022, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Encoding tissue morphogenesis with genetics, mechanics and geometry

Professor Thomas Lecuit, Group leader at IBDM and Turing Center for living systems, Marseille. Professor at Collège de France, Paris.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91594582633?pwd=UlBaTk1uTHJ4bW9JbFMwSEZxRE0zdz09.

Thursday 08 September 2022, 11:00-12:00

MRC LMB Seminar Series

Milstein Lecture 2022 - Project Lightspeed – The discovery of the first Covid-19 mRNA Vaccine

Özlem Türeci, M.D., Professor Personalized Cancer Immunotherapy, Johannes Gutenberg University Mainz, Co-founder, CMO BioNTech, Germany.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

Tuesday 26 July 2022, 11:30-12:30

MRC LMB Seminar Series

Milstein Lecture 2022 - mRNA Cancer Vaccines

Ugur Sahin, M.D., Professor Translational Oncology & Immunology, Johannes Gutenberg University Mainz, Co-founder, CEO BioNTech, Germany.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

Tuesday 26 July 2022, 10:00-11:00

MRC LMB Seminar Series

LMB Seminar - Using connectomes to accelerate studies of the neuronal control of behavior in Drosophila

Gerald M. Rubin, Senior Group Leader, Janelia Research Campus, HHMI, LMB Fellow.

In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91661708050?pwd=WS9Ua0czQm9FaC9qaWk3S2VQMjE5dz09.

Thursday 26 May 2022, 11:00-12:00

MRC LMB Seminar Series

Aaron Klug Memorial Symposium

Various - see Further Information.

Registration via https://www3.mrc-lmb.cam.ac.uk/sites/klug/.

Friday 20 May 2022, 09:00-17:00

MRC LMB Seminar Series

Kendrew Lecture 2022: Chemogenetic and optogenetic technologies for probing molecular and cellular networks

Alice Ting - Professor of Genetics, of Biology and, by courtesy, of Chemistry, Stanford University, USA and Chan Zuckerberg Biohub Investigator .

Zoom link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99780084619?pwd=V3RmYTdTbmlBLzFLd1NOR0hHcjFIZz09.

Thursday 12 May 2022, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: Engineering Organoid Development

Professor Matthias Lutolf, Roche Institute for Translational Bioengineering, Basel, Switzerland and Laboratory of Stem Cell Bioengineering, EPFL, Switzerland.

Zoom link: https://mrc-lmb-cam-ac-uk.zoom.us/j/97051627883?pwd=cUh3ZDZkT3I2bHdxVXo0TytZSEJkdz09.

Tuesday 19 April 2022, 11:00-12:00

MRC LMB Seminar Series

Max Perutz Lecture 2022: Therapeutic Opportunities in Glycoscience

Carolyn Bertozzi, Anne T. and Robert M. Bass Professor of Chemistry, Baker Family Director, Stanford ChEM-H, Howard Hughes Medical Institute Investigator, Stanford University.

Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/92288963882?pwd=MEFqUURaRmJ1dkpTNkl1dzhDcHE2QT09.

Tuesday 29 March 2022, 16:00-17:00

MRC LMB Seminar Series

Milstein Lecture 2021: Organoids to model human diseases

Hans Clevers, Professor in Molecular Genetics, Hubrecht Institute, Utrecht, The Netherlands.

Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/96610458150?pwd=RmI5RUZZU0JRNzBBNlh3NnFWQWpjZz09.

Tuesday 30 November 2021, 11:00-12:00

MRC LMB Seminar Series

Crick Lecture 2021: Human Immune Responses to SARS-CoV-2 Infection or Vaccination

Michel C. Nussenzweig, Zanvil A. Cohn and Ralph M. Steinman Professor, The Rockefeller University, New York, USA.

Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/98167346283?pwd=UStva0JBNFpiNTE4czlSS283WGJlQT09.

Monday 15 November 2021, 11:00-12:00

MRC LMB Seminar Series

Interplay between tissue tension and tumor immunity

Valerie Weaver, Director of the Center for Bioengineering and Tissue Regeneration and Professor in the Department of Surgery, UCSF, USA.

Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/92866604568?pwd=TlljTHk5VGEzd2YzM3JHQkxOaWdRUT09.

Tuesday 02 November 2021, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: Biomolecular condensates and their implications for physiology and disease

Tony Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Webinar - https://zoom.us/j/92425532683?pwd=bXhPUkh0dm8xRlVmUkthREQwUnc4UT09.

Tuesday 19 October 2021, 11:00-12:00

MRC LMB Seminar Series

LMB Kendrew Lecture (part 2): Highly accurate protein structure prediction with AlphaFold

John Jumper, Research scientist and AlphaFold lead.

YouTube link to watch the talk: https://youtu.be/6hlgADbBvZs.

Wednesday 13 October 2021, 16:00-17:00

MRC LMB Seminar Series

LMB Kendrew Lecture (part 1): Using AI to accelerate scientific discovery

Demis Hassabis, Founder & CEO DeepMind, AlphaFold project lead.

YouTube link to watch the talk: https://youtu.be/6hlgADbBvZs.

Wednesday 13 October 2021, 14:30-15:30

MRC LMB Seminar Series

Using stem cell technology to combat age-related neurodegenerative diseases

Sally Temple PhD, Scientific Director, Neural Stem Cell Institute, USA.

Webinar - https://zoom.us/j/99447632193?pwd=QU9vbXliNXcvcXZqVFFBbHVpd2tSUT09.

Tuesday 27 July 2021, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: The biomass distribution on Earth

Ron Milo, Professor, Department of Plant and Environmental Sciences, Weizmann Institute of Science, Israel.

Webinar - https://zoom.us/j/93763520674?pwd=WTlDZThITTFUaEpKL2xMZ1YzZWVkZz09.

Tuesday 06 July 2021, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Membrane Mechanics: cryo-EM insights and challenges

Adam Frost, Associate Professor, Biochemistry and Biophysics, UCSF, USA.

Webinar - https://zoom.us/j/97224999053?pwd=aitsUFFSQ3dKVlM0MUFVWC83S0E0UT09.

Tuesday 29 June 2021, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: Mechanisms of centriole assembly

Pierre Gönczy, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Webinar - https://zoom.us/j/91953336333?pwd=ZnV2R1dNSW1FdVhmK1J6UmcvdnNOdz09.

Tuesday 22 June 2021, 11:00-12:00

MRC LMB Seminar Series

Mechanisms of centriole assembly

Pierre Gönczy, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Webinar - https://zoom.us/j/91953336333?pwd=ZnV2R1dNSW1FdVhmK1J6UmcvdnNOdz09.

Tuesday 22 June 2021, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Systemic regulation of brain aging and function

Tony Wyss-Coray, D. H. Chen Professor II, Stanford University, USA.

Webinar - Zoom link: https://zoom.us/j/91691820397?pwd=aUNFUFFib1V5S2V4RUswRmlhN0pRQT09.

Tuesday 25 May 2021, 16:00-17:00

MRC LMB Seminar Series

Perutz Lecture 2021: The coming of age of de novo protein design

Professor David Baker, Director of the Institute for Protein Design, University of Washington, USA .

Webinar - https://zoom.us/j/92141784758?pwd=MC9UVVBLaUdkTkg4dDdJb2RRaGhmUT09.

Tuesday 27 April 2021, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar: Molecular views into cellular functions by in-cell cryo-electron tomography

Dr Julia Mahamid, Group Leader, EMBL Heidelberg, Germany.

Webinar - https://zoom.us/j/97074945822?pwd=NWZvc3VEVWJxWmREVXJhaisxTkJ5dz09.

Tuesday 20 April 2021, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Functions of Ribosome-Associated Chaperones in Health and Disease

Prof. Dr. Elke Deuerling, Chair of Molecular Microbiology, University of Konstanz, Germany.

Webinar - https://zoom.us/j/97041423092?pwd=dDFuelNtb0o2cTdWL1BabFBhbldFQT09 .

Tuesday 16 March 2021, 11:00-12:00

MRC LMB Seminar Series

Rules of engagement: molecular arms races between host and viral genomes

Dr. Harmit Singh Malik, Professor, Division of Basic Sciences & HHMI Investigator, Fred Hutchinson Cancer Research Center.

Webinar - https://zoom.us/j/92208122335?pwd=UGJIN3k3TnJYNWloNFBhVDlOaldZUT09.

Tuesday 02 March 2021, 16:00-17:00

MRC LMB Seminar Series

Translation defects and neurological disease

Susan L Ackerman, PhD. Professor, Cellular and Molecular Biology Steven W. Kuffler Chair of Biology University of California San Diego USA/HHMI.

Webinar - https://zoom.us/j/95280655660?pwd=RzhzSlQvWXFVS1dVdURPUUxocElkQT09 Passcode: 628922.

Tuesday 08 December 2020, 16:00-17:00

MRC LMB Seminar Series

Sir Martin Wood Prize Lecture: The emerging world of microbial rhodopsins in photobiology

Keiichi Inoue, Associate Professor, The Institute for Solid State Physics, The University of Tokyo.

Webinar - register at https://nanoscience.oxinst.com/campaigns/sir-martin-wood-prize-lecture.

Thursday 26 November 2020, 11:00-12:00

MRC LMB Seminar Series

The African killifish: a vertebrate model to understand aging and ‘suspended animation'

Anne Brunet, Michele and Timothy Barakett Professor of Genetics, Stanford University, USA.

Webinar (via Zoom online).

Tuesday 03 November 2020, 16:00-17:00

MRC LMB Seminar Series

How is electrical signal generated?

Nieng Yan, Shirley M. Tilghman Professor of Molecular Biology, Princeton University, USA.

Webinar via Zoom.

Monday 02 November 2020, 16:00-17:00

MRC LMB Seminar Series

RNP granules in health and disease (via Zoom)

Roy Parker, Investigator, Howard Hughes Medical Institute, Executive Director, BioFrontiers Institute, Distinguished Professor and Cech-Leinwand Endowed Chair of Biochemistry, University of Colorado Boulder, USA.

Webinar via Zoom.

Tuesday 22 September 2020, 16:00-17:00

MRC LMB Seminar Series

Study virus assembly and host interactions in vitro and in cells by cryoEM and cryoET

Peijun Zhang, Professor of Structural Biology and Wellcome Trust Investigator, University of Oxford .

Webinar via Zoom - https://zoom.us/j/97493748184?pwd=Z1dZM2pxUk16QytPeU5NVWZ3bnZmdz09 Meeting ID: 974 9374 8184 Passcode: 404662.

Tuesday 08 September 2020, 11:00-12:00

MRC LMB Seminar Series

Perutz LMB Seminar Series: How our chromosomes are replicated

John Diffley, Associate Research Director, the Francis Crick Institute, London, UK.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 26 February 2020, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar: Mitochondrial Behaviour

Jodi Nunnari, Distinguished Professor, Department of Molecular and Cellular Biology, Univeristy of California, Davis.

Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology.

Tuesday 25 February 2020, 16:00-17:00

MRC LMB Seminar Series

Milstein LMB Seminar Series: Stem Cells in Silence, Action and Cancer

Elaine Fuchs, Rebecca C. Lancefield Professor Investigator, Howard Hughes Medical Institute .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 27 January 2020, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series: Host factors that shape influenza evolution.

Wendy Barclay.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 06 December 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series: Folding and assembly of newly synthesized proteins revealed by ribosome profiling

Bernd Bukau, Center for Molecular Biology of Heidelberg University and German Cancer Research Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 21 November 2019, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series - Kendrew Lecture - How a ubiquitin-like protein brings ubiquitylation to life

Brenda Schulman, Director at the Max Planck Institute of Biochemistry.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 03 October 2019, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series - Organelle contact sites: a new layer in the organization of Eukaryotic cells

Benoit Kornmann, Associate professor – Dept. of Biochemistry, Oxford University, and C.W. Maplethorpe Tutorial Fellow in Bio-chemistry – St-Hugh’s College, Oxford University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 12 September 2019, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series - Antibodies against Ebola and Lassa: A Global Collaboration

Erica Ollmann Saphire, Professor Department of Immunology and Microbiology California Campus.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 23 July 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series - Francis Crick Lecture - Innovation by Evolution: Bringing New Chemistry to Life

Frances Arnold, California Institute of Technology, Pasadena, U.S.A..

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 18 July 2019, 16:00-17:00

MRC LMB Seminar Series

What next for your career in science?

Rebecca Aarons, Jenny Gallop, Emma Gleave.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 28 June 2019, 12:00-13:00

MRC LMB Seminar Series

LMB Seminar Series - Structural and mechanistic studies of key components in DNA damage signalling and repair

Xiaodong Zhang.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 18 June 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series: Folding and assembly of newly synthesized proteins revealed by ribosome profiling

Bernd Bukau, Center for Molecular Biology of Heidelberg University and German Cancer Research Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 14 June 2019, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series - Towards a mechanistic understanding of cellular processes by cryo-EM

Gaia Pigino, Research Group Leader at the MPI-CBG.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 28 May 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series - The 100,000 genomes project and beyond

Tim Hubbard, Professor of Bioinformatics & Head of Department, King’s College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 23 May 2019, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series: Title tbc

Nieng Yan, Professor of Molecular Biology, Princeton University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Saturday 18 May 2019, 00:00-00:00

MRC LMB Seminar Series

LMB Seminar Series - Modifications of RNA: their function and role in cancer

Tony Kouzarides, PhD FRS FMedSci, Professor of Cancer Biology, Cancer Research UK Gibb Fellow, Director of the Milner Therapeutics Institute, Member of the Department of Pathology.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 16 May 2019, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series - Synthesis and hydrolysis of the gram-positive cell wall: revisiting old models with new data

David Rudner, Dept. of Microbiology and Immunobiology, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 03 May 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series - CryoEM of proton pumping macromolecular machines

John Rubinstein.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 29 April 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series - Factors and Functions of ER Membrane Contact Sites

Gia Voeltz PhD, HHMI Investigator and Professor University of Colorado at Boulder.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 10 April 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series - Pathogen restriction and host specificity: insights from the human pathogen Salmonella Typhi

Jorge Galan, PhD, DVM, Lucille P. Markey Professor of Microbial Pathogenesis and Professor of Cell Biology; Chair, Department of Microbial Pathogenesis.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 April 2019, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series: Title tbc

Gerry Rubin, Vice President, HHMI, and Executive Director, Janelia Research Campus.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 03 April 2019, 00:00-00:00

MRC LMB Seminar Series

LMB Seminar Series: Title tbc

Gerry Rubin, Vice President, HHMI, and Executive Director, Janelia Research Campus.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 03 April 2019, 00:00-00:00

MRC LMB Seminar Series

LMB Seminar Series: Title tbc

Julie Ahringer, PhD FMedSci, Director, Wellcome Senior Research Fellow, Professor of Genetics and Genomics, Member of the Department of Genetics.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 27 March 2019, 00:00-00:00

MRC LMB Seminar Series

LMB Seminar Series: Title tbc

Julie Ahringer, PhD FMedSci, Director, Wellcome Senior Research Fellow, Professor of Genetics and Genomics, Member of the Department of Genetics.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 27 March 2019, 00:00-00:00

MRC LMB Seminar Series

LMB Seminar Series - ANNA KARENINA AND THE GENETICS OF COMPLEX DISEASE: DE NOVO MUTATIONS IN SCHIZOPHRENIA

Mary-Claire King, human geneticist professor, University of Washington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 14 March 2019, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series - Animating Molecular Biology

Janet Iwasa, Assistant Professor, Biochemistry Department, University of Utah.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 08 March 2019, 11:30-12:30

MRC LMB Seminar Series

LMB Seminar Series Milstein Lecture - Intracellular Membrane Contact Sites, Lipid Dynamics and Neurodegeneration

Pietro De Camilli Departments of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscince, Yale University School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 05 March 2019, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series - Stem cells, regeneration and organoid cultures

Meritxell Huch, Wellcome Sir Henry Dale Fellow, Member of the Department of Physiology, Development and Neuroscience.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 28 February 2019, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

tRNA Modifications and Decoding Errors

Professor Eric Westhof (Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg).

Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Wednesday 20 February 2019, 16:00-18:00

MRC LMB Seminar Series

LMB Seminar Series-Epigenetic inheritance in mammals

Anne Ferguson Smith, Department of Genetics, Wellcome Trust Senior Investigator.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 30 January 2019, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A Saposin-lipoprotein nanoparticle system for membrane proteins

Dr Jens Frauenfeld (CEO Salipro Biotech, Sweden).

Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Monday 03 December 2018, 15:00-17:00

MRC LMB Seminar Series

LMB Seminar Series-Solving a 3D jigsaw with 1000 pieces - Structure and assembly of the nuclear pore complex

Martin Beck.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 03 December 2018, 11:00-12:00

MRC LMB Seminar Series

Perutz Lecture- How synapses work: Architecture and mechanism of neurotransmitter receptors and transporters

Eric Gouaux.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 29 November 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Capturing the 3D Folds of Whole Mammalian Genomes in Single Cells

Dr Tim Stevens (Cell Biology Division, LMB).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 28 November 2018, 10:15-11:15

MRC LMB Seminar Series

LMB Seminar Series-Title to follow

Carrie Partch.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 20 November 2018, 11:00-12:00

MRC LMB Seminar Series

Reconstructing Tissue Architecture by Single Cell Genomics

Sarah Teichmann.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 15 November 2018, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series-Mycobacterium tuberculosis infection of host cells in time and space

Max Gutierrez.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 01 November 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein:protein recognition in the Ubiquitin Proteasome-degradation System (UPS) and Membrane Surface Complexes from the Ras-family

Dr Andrew Byrd (Head of Macromolecular NMR, National Cancer Institute, Maryland).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 31 October 2018, 16:00-18:00

MRC LMB Seminar Series

Light Sleep

Gero Miesenboeck.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 24 October 2018, 11:00-12:00

MRC LMB Seminar Series

Evidence that sub-cellular oscillators may time and execute organelle biogenesis

Jordan Raff.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 20 September 2018, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series - Kinetochore Structure

Steve Harrison.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 28 June 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of a DNA unwinding machine

Dr Laura Spagnolo (University of Glasgow).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Architecture of PIKK Kinases and their molecular mechanisms of regulation

Dr Taiana De Oliveira (Astra Zeneca).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein and Peptide Mass Spectrometry Analysis

Dr Anja Andrejeva (Cambridge Centre for Proteomics).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 06 June 2018, 10:30-11:30

MRC LMB Seminar Series

LMB Seminar Series-Title to follow

Michael Hall.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 29 May 2018, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series-Title to follow

Titia De Lange Rockefeller.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 23 May 2018, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Solution-based angular measurements of protein structure and conformational change by second-harmonic generation (SHG)

Dr Joshua Salafsky (Founder and CSO, Biodesy Inc, San Francisco).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 23 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment based inhibition of CK2α

Dr Paul Brear (Hyvonen Group).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 16 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Correlative tweezers fluorescence microscopy: one step towards real-time single-molecule biology

Dr Joanna Andrecka (Lumicks).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 09 May 2018, 10:30-11:30

MRC LMB Seminar Series

Kendrew Lecture-Electron cryo-microscopy

Jacques Dubochet.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 April 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Substrate reduction enabled by structural biology as therapy for metabolic disorders

Dr Gustavo Arruda Bezerra (Structural Genomics Consortium – University of Oxford).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 25 April 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level

Dr Luay Joudeh (Pellegrini Group).

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 March 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil

Dr Pedro Torres.

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 March 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours

Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd).

Biochemistry Seminar Room, Sanger Building.

Monday 19 March 2018, 10:15-11:15

MRC LMB Seminar Series

LMB Seminar Series-Title to follow

Lukas Kapitein.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 15 March 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance

Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa).

Biochemistry Seminar Room, Sanger Building.

Wednesday 07 March 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis

Professor W. Jacobs, Howard Hughes Medical Institute, NY.

Biochemistry Seminar Room, Sanger Building.

Monday 26 February 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Human 2-oxoacid-dependent Oxygenases

Dr M. S. Islam (Department of Biochemistry, University of Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 January 2018, 10:30-11:15

MRC LMB Seminar Series

Kendrew Lecture- Illuminating biology at the nanoscale and systems scale by imaging

Xiaowei Zhuang .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 January 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942

Dr Robert Greenstein (VA Medical Center, Bronx, NY).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 December 2017, 10:15-11:15

MRC LMB Seminar Series

Localised RNA-based mechanisms underlie neuronal wiring

Christine Holt.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 04 December 2017, 11:00-12:00

MRC LMB Seminar Series

Exploring and Exploiting the Diversity of Secretory Routes in Mammalian Cells

Franck Perez.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 28 November 2017, 14:00-15:00

MRC LMB Seminar Series

Genomic and cellular integration of bacterial endosymbionts into host cells

John McCutcheon.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 03 November 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Signalling through interleukin/interferon receptors: outside and inside of the cell

Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick).

Biochemistry Seminar Room, Sanger Building.

Wednesday 11 October 2017, 10:15-11:15

MRC LMB Seminar Series

LMB Seminar Series- Stories from the first year of the Central Oxford Structural Microscopy and Imaging Centre - closing in on bacterial protein secretion systems.

Susan Lea.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 02 October 2017, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series- How T cells control secretion to optimise target cell killing

Gillian Griffiths.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 19 September 2017, 11:00-12:00

MRC LMB Seminar Series

Crick Lecture-The Surprising Chemistry of Non-enzymatic RNA Replication

Jack Szostack, Harvard, USA .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 September 2017, 16:00-17:00

MRC LMB Seminar Series

Integrated structural biology of gene transcription

Patrick Cramer, Max Planck Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 05 September 2017, 16:00-12:00

MRC LMB Seminar Series

LMB Seminar Series-RNA quality control and the nuclear RNA exosome

Chris Lima.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 14 July 2017, 11:00-12:00

MRC LMB Seminar Series

LMB Seminar Series- Title to follow

Andreas Matouschek, Northwestern University, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 03 July 2017, 16:00-17:00

MRC LMB Seminar Series

LMB Seminar Series-DNA Methylation: From stem cell differentiation to chromatin organisation

Margaret Goodell.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 20 June 2017, 11:15-12:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia

Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 31 May 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Revolutionary Cryo-EM: the Potential Power to Visualize High Resolution Dynamic Structures

Dr Kai Zhang (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 May 2017, 10:15-11:15

MRC LMB Seminar Series

Charting the response to DNA damage

Dan Durocher, University of Toronto, Faculty of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 May 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology

Dr David Schriemer (University of Calgary, Alberta).

Biochemistry Seminar Room, Sanger Building.

Wednesday 10 May 2017, 10:15-11:15

MRC LMB Seminar Series

Mulitispectral imaging to uncover the organelle interactome

Jennifer Lippincott-Schwartz, National Institute of Health, Maryland, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 08 May 2017, 16:00-17:00

MRC LMB Seminar Series

Max Perutz Lecture- Antisense transcription and epigenetic switching

Caroline Dean, John Innes Centre, Norwich.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 April 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD!

Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford).

Biochemistry Seminar Room, Sanger Building.

Monday 03 April 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

COSMIC Catalogue of Cancer Mutations and the 3D Proteome

Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus).

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 March 2017, 10:15-11:15

MRC LMB Seminar Series

RNA methylation in development and disease

Michaela Frye, Stem Cell Institute and Department of Genetics, Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 24 March 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies

Dr Monika Fuxreiter.

Biochemistry Lecture Theatre, Sanger Building.

Thursday 23 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Integrative Methods in Structural Biology to Understand Protein Structure

Dr Daniel Saltzberg (University of California, San Francisco).

Biochemistry Seminar Room, Sanger Building.

Wednesday 08 March 2017, 10:15-11:15

MRC LMB Seminar Series

Membrane proteins - the lipid connection

Carol Robinson, university of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 07 March 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Computational study of mutations in proteins

Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil).

Biochemistry Seminar Room, Sanger Building.

Wednesday 01 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation

Prof Maria Sunnerhagen (Linkoping University, Sweden).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 28 February 2017, 14:30-15:30

MRC LMB Seminar Series

Milstein Lecture- Molecular Mechanisms of Synaptic Transmission

Thomas Südhof, Department of Molecular and Cellular Physiology, Stanford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 09 February 2017, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

What's new at PDBe?

Dr Deepti Gupta and Dr John Berrisford (PDBe).

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 January 2017, 10:15-11:15

MRC LMB Seminar Series

Comparative studies of intrinsically disordered proteins

Professor Jane Clarke, Department of Chemistry, University of Cambridge .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 23 January 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome

Prof David Litchfield (University of Western Ontario).

Biochemistry Seminar Room, Sanger Building.

Wednesday 16 November 2016, 14:30-16:00

MRC LMB Seminar Series

Molecular Chaperone Functions in Protein Folding and Quality Control

Ulrich Hartl, max Planck Institute of Biochemistry.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 November 2016, 12:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A computational framework for optimizing combination drug therapies

Dr Michael Lyons (Colorado State University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 October 2016, 10:15-11:15

MRC LMB Seminar Series

Kendrew Lecture- Bacterial Quorum Sensing and its Control

Bonnie Bassler, Princeton University, USA .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 24 October 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structure and Function of TIFA - A New Player in Immunity and Cancer

Prof Ming-Daw Tsai (Academia Sinica in Taiwan).

Biochemistry Seminar Room, Sanger Building.

Monday 10 October 2016, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Interactive molecular dynamics for improved model building and exploration in structural biology

Dr Tristan Croll (CIMR, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 September 2016, 10:15-11:15

MRC LMB Seminar Series

TBC

Amita Sehgal.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 27 September 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting the impact of natural and disease variants on protein function

Professor Rob Russell (Heidelberg University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 July 2016, 10:15-11:15

MRC LMB Seminar Series

TBC

Laurence Pearl, Sussex.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 12 July 2016, 11:00-12:00

MRC LMB Seminar Series

TBC

Richard Youle.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 01 July 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis

Nupur Verma (Department of Biochemistry, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 15 June 2016, 10:15-11:15

MRC LMB Seminar Series

Pathological vs Reversible Amyloid

David Eisenberg, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 10 June 2016, 11:00-12:00

MRC LMB Seminar Series

Pathological vs Reversible Amyloid

Prof. David Eisenberg, Dept. Chemistry and Biochemistry, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 10 June 2016, 11:00-12:00

MRC LMB Seminar Series

Perutz Lecture 2016

Ron Vale, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 02 June 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

TBC

Dr Owen Davies (Newcastle University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 01 June 2016, 10:15-11:15

MRC LMB Seminar Series

Kendrew lecture- Post-translational regulation of cell signalling

Tony Hunter.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 25 May 2016, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models

Dr Agnel Praveen Joseph.

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 May 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The 3D structures of genomes in single cells reveal principles of nuclear organization

Dr Tim Stevens (LMB, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 May 2016, 10:15-11:15

MRC LMB Seminar Series

Mapping cancer origins

Proffessor Richard Gilbertson, Cancer Research UK, Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 03 May 2016, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The E. coli replisome caught in the act by cryo-EM and single molecule microscopy

Dr Meindert Lamers (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 April 2016, 14:00-15:00

MRC LMB Seminar Series

Learning and motivation toggle feed-forward inhibition in the Drosophila mushroom body

Scott Waddell.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 27 April 2016, 11:00-12:00

MRC LMB Seminar Series

CRISPR-Cas: origin of adaptive immunity from selfish genetic elements and the evolutionary continuum from Darwin to Lamarck

Eugene Koonin.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 18 March 2016, 11:00-12:00

MRC LMB Seminar Series

Structure of TRP channel by single particle cryo-EM

Yifan Cheng.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 16 March 2016, 11:00-12:00

MRC LMB Seminar Series

Cell wall deficient (L-form) bacteria: from cell biology to the origins of life

Jeff Errington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 03 March 2016, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Pregnancy outcome prediction using placenta epigenetic data

Dr Sung Gong (Clinical School of Medicine).

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 March 2016, 10:15-11:15

MRC LMB Seminar Series

mRNA stability is substantially dictated by the action of the ribosome

Rachel Green, Johns Hopkins University, School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 25 February 2016, 10:30-11:30

MRC LMB Seminar Series

Crick 2016 Lecture-DNA Sequence and the Epigenome Entwined

Adrian Bird.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 16 February 2016, 11:30-12:30

MRC LMB Seminar Series

A chemical approach to understanding cell division

Ulrike Eggert.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 02 February 2016, 16:15-17:15

MRC LMB Seminar Series

Protein folding homeostasis in the endoplasmic reticulum: tuning a chaperone

David Ron, University of Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 29 January 2016, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein transport to the endoplasmic reticulum

Dr Rebecca Voorhees (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 20 January 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Computational approaches to investigate protein-nucleic acid and protein-protein interactions

Dr Sony Malhotra (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 16 December 2015, 10:15-11:15

MRC LMB Seminar Series

Milstein Lecture-Phosphoinositide 3-Kinase and Cancer Metabolism

Lewis Cantley, Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital, New York.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 14 December 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mapping of ligand binding site and activation mechanism of APJ receptor

Prashant Kumar (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 December 2015, 10:15-11:15

MRC LMB Seminar Series

In the beginning it was dark: Hydrothermal vents and the origin of life (real microbes)

William Martin, Universität Düsseldorf.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 November 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Paul Brear - Inhibiting CK2α from outside the active site

Paul Brear - Department of Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Prof Song Tan - TBC

Professor Song Tan (Penn State University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fitting atomic structures into EM density maps

Dr Arun Prasad Pandurangan (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 04 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A"

Xuelu Wang and Migle Kisonaite - Department of Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 October 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

ARCIMBOLDO, an ab initio approach to MR phasing

Isabel Uson (Molecular Biology Institute of Barcelona).

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 October 2015, 10:15-11:15

MRC LMB Seminar Series

Crick Lecture- The transformative CRISPR-Cas9 genome engineering technology: lessons learned from bacteria

Emmanuelle Charpentier .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 02 October 2015, 15:15-16:15

MRC LMB Seminar Series

Plasticity of Cancer Cells : Lessons from Glioblastoma

Inder Verma, Salk Institute for Biological Studies.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 04 September 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Atomic resolution cryoEM structure of bacteriophage

Prof. Wah Chiu, Baylor College of Medicine, Texas.

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 September 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Modulating Protein-Protein Interactions

Dr Jessica Holien - St. Vincent's Institute for Medical Research.

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 August 2015, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 June 2015, 10:15-11:15

Centre for Molecular Science Informatics

Crystallography & Compchem Hack Weekend 20/21 June

Speaker to be confirmed.

Centre for Molecular Informatics, Dept. of Chemistry.

Saturday 20 June 2015, 09:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC

Jia-Huai Wang (Harvard).

Biochemistry Seminar Room, Sanger Building.

Wednesday 17 June 2015, 10:15-11:15

MRC LMB Seminar Series

Persister Cells and the Search for Sterilizing Antibiotics

Kim Lewis.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 June 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Impact of rapid whole-genome sequencing on diagnostic and public health microbiology

Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus.

Biochemistry Seminar Room, Sanger Building.

Wednesday 03 June 2015, 10:15-11:15

MRC LMB Seminar Series

Structural Mechanisms in the Tyrosine Kinases that Initiate Immunological Signaling

Professor John Kuriyan, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 21 May 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Mechanisms in Protein Kinase Regulation

Professor John Kuriyan, Berkeley.

Biochemistry Seminar Room, Sanger Building.

Wednesday 20 May 2015, 10:15-11:15

MRC LMB Seminar Series

Regulation of proteasome function in normal and disease states

Professor Alfred Goldberg, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 15 May 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting drug-target binding kinetics through enhanced sampling simulations

Professor Francesco Gervasio, Dept. Chemistry, University College London.

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 May 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Biodiversity and Drug Discovery

Professor Glaucius Oliva, Universidade de São Paulo.

Biochemistry Seminar Room, Sanger Building.

Thursday 07 May 2015, 16:30-17:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Recent advances in high resolution cryo-EM structure determination

Xiaochen Bai, LMB-MRC.

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 April 2015, 10:15-11:30

MRC LMB Seminar Series

Chromatin unloading of the replicative DNA helicase during replication and repair

Johannes Walter.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 08 April 2015, 16:15-17:15

MRC LMB Seminar Series

Insights from a model of breast tumor heterogeneity

Greg Hannon, CRUK, Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 March 2015, 16:15-17:15

MRC LMB Seminar Series

Remodeling of the erythroid proteome

Dan Finley, Harvard.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 17 March 2015, 16:15-18:00

MRC LMB Seminar Series

Synthetic Probes for live-cell imaging

Kai Johnsson.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 11 March 2015, 16:15-18:00

MRC LMB Seminar Series

Tbc

Jeff Errington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 03 March 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Meindert Lamers - Title to be confirmed

Dr Meindert Lamers - LMB.

Biochemistry Seminar Room, Sanger Building, Tennis Court Road.

Wednesday 25 February 2015, 10:15-11:15

MRC LMB Seminar Series

Prion propagation and neurotoxicity

Prof. John Collinge, UCL .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 February 2015, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Isaac Westwood - Title to be Confirmed

Dr Isaac Westwood - Institute of Cancer Research.

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 February 2015, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Christian Ottmann, Title to be confirmed

Dr. Christian Ottmann Associate Professor, (UHD) Molecular Cell and Structural Biology, Chemical Biology, Dpt. of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit, EINDHOVEN.

Biochemistry Seminar Room, Sanger Building.

Wednesday 04 February 2015, 10:15-11:15

MRC LMB Seminar Series

Taming a protein destruction machine

Nicolas Thoma, Friedrich Miescher Institute for Biomedical Reearch, Basel, Switzerland.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 29 January 2015, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design

Dr Paula de Fonseca - MRC LMB.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 January 2015, 10:15-11:30

MRC LMB Seminar Series

Title to be confirmed

David Ron, Cambridge University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 27 January 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Takashi Ochi and Dr Qian Wu

Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k.

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 January 2015, 10:15-11:30

MRC LMB Seminar Series

Local and Global Regulation of Meiotic Prophase by Post-Translational Protein Modification

Neil Hunter.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 December 2014, 16:15-18:00

MRC LMB Seminar Series

Max Perutz Lecture 2014: C. elegans surveillance of conserved cellular components to detect and defend pathogen attacks, real or imagined

Gary Ruvkun, MGH Harvard.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 December 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tools for refinement against low resolution X-ray data and fit to EM reconstructions

Dr Garib Murshudov, LMB, MRC.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Wednesday 03 December 2014, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets

Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain.

Biochemistry Seminar Room, Sanger Building.

Wednesday 12 November 2014, 10:15-11:15

MRC LMB Seminar Series

The amazing hepatocyte: master of disguise and adaptation

Dr Markus Grompe.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 10 November 2014, 16:15-18:00

MRC LMB Seminar Series

Genome stability and instability during repair of a broken chromosome

Jim Haber, Director, Rosenstiel Basic Medical Sciences Research Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 06 November 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

(1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR

Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific.

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 October 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Support Science and Diamond Light Source

Carina Lobley, DLS.

Biochemistry Seminar Room, Sanger Building.

Wednesday 15 October 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Professor Randy Read - title to be comfirmed

Professor Randy Read, CIMR, Cambridge.

Seminar Room 2, Hopkins Building.

Wednesday 08 October 2014, 10:15-11:15

MRC LMB Seminar Series

Crick Lecture 2014: How Aneuploidy Drives Cancer

Stephen Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 19 September 2014, 16:15-18:00

MRC LMB Seminar Series

Feedback control of cell division

Andrea Musacchio, Director, Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 18 September 2014, 16:15-18:00

MRC LMB Seminar Series

From static structures to molecular movies: pushing the boundaries of X-ray Crystallography

Wei Yang, NIH, Bethesda, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 September 2014, 16:15-18:00

MRC LMB Seminar Series

The Consequences of Whole Genome Duplications

Prof David Pellman, Professor of Cell Biology, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 22 July 2014, 16:15-18:00

MRC LMB Seminar Series

Extrinsic regulation of haematopoietic stem cell self

Sean J. Morrison Investigator, Howard Hughes Medical Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 July 2014, 11:45-13:30

Centre for Molecular Science Informatics

Interacting with Protein Interactions

"Special Event" Cambridge Cheminformatics Network Meetings

Professor Arthur J Olson, Departmen of Interactive Structure & Computational BIology, The Scripps Research Institute, La Jolla CA.

Pfizer Lecture Theatre Department of Chemistry Lensfield Road Cambridge Cambridgeshire CB2 3RA.

Wednesday 09 July 2014, 16:00-17:00

MRC LMB Seminar Series

Milstein Lecture 2014: Unfolded Protein Response in Health and Disease

Peter Walter, University of California, San Francisco .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 30 June 2014, 16:15-18:00

MRC LMB Seminar Series

The function and execution of RTEL1 activities at vertebrate telomeres

Dr Simon Boulton, DNA damage Response Laboratory, London Research Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 27 June 2014, 16:15-18:00

MRC LMB Seminar Series

Exploring the final events in eukaryotic cell division

Juan Martin-Serrano, Kings College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 June 2014, 16:15-18:00

MRC LMB Seminar Series

TBC

Juan Martin-Serrano.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 June 2014, 16:15-18:00

Centre for Molecular Science Informatics

Synergism between Theory and Experiments in Asymmetric Catalysis: Transition State Modeling for Rationalizations and Catalyst Design

Professor Raghavan B. Sunoj, Department of Chemistry, Indian Institute of Technology, Bombay.

Unilever Lecture Theatre, Department of Chemistry.

Thursday 19 June 2014, 14:15-15:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair

Professor Xiaodong Zhang Imperial College London Department of Life Sciences.

Biochemistry Seminar Room, Sanger Building.

Wednesday 11 June 2014, 10:15-11:15

Centre for Molecular Science Informatics

"CADD & ENAC - A bad hand at Scrabble..?"

Please note that the date of this seminar has been changed

Dr Peter Hunt, Optibrium Ltd.

Unilever Lecture Theatre, Department of Chemistry.

Tuesday 03 June 2014, 14:15-15:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity

Monique Gangloff, Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 May 2014, 10:15-11:15

MRC LMB Seminar Series

Engineering strategies for tuning cell surface receptor signalling

K. Christopher Garcia, Stanford University School of Medicine .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 14 May 2014, 16:15-18:00

Centre for Molecular Science Informatics

Visualization of Chemical Space for Medicinal Chemists

Dr Peter Ertl, Novartis, Basel, Switzerland.

Unilever Lecture Theatre, Department of Chemistry.

Tuesday 06 May 2014, 14:15-15:30

Centre for Molecular Science Informatics

"From fragments to target-selective ligands by reaction-driven de novo design"

Professor Gisbert Schneider. Institute of Pharmaceutical Sciences ETH Zurich.

Pfizer Lecture Theatre, Department of Chemistry.

Monday 28 April 2014, 14:15-15:30

MRC LMB Seminar Series

Structural basis of protein PARylation-dependent ubiquitination

Rachel Klevit, University of Washington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 24 April 2014, 16:15-18:00

MRC LMB Seminar Series

Francis Crick Lecture 2014: Prions Causing Neurodegeneration: A Unifying Etiology and the Quest for Therapeutics

Stanley Prusiner, University of California San Francisco .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 11 April 2014, 15:00-17:00

MRC LMB Seminar Series

What can NMR tell us about how a virus enters its host cell?

Ad Bax, NIH.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 April 2014, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

How insulin binds to the insulin receptor: structural biology and protein engineering

Dr Michael Weiss, School of Medicine Cleveland, USA.

Biochemistry Seminar Room, Sanger Building.

Wednesday 09 April 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome

Dr Alan Brown.

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 April 2014, 10:15-11:15

MRC LMB Seminar Series

Building proteins de novo: better, faster, fitter

Dek Woolfson, University of Bristol.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 March 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Coot's EM Model-fitting Tools

Dr Paul Emsley, MRC-LMB, Cambridge, U.K..

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 March 2014, 10:15-11:15

MRC LMB Seminar Series

John Kendrew Lecture 2014: Birth and Future of Multi-Scale Modeling of Macromolecules

Michael Levitt, Standford Unversity.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 25 March 2014, 16:15-18:00

Centre for Molecular Science Informatics

Odorant space: From chemistry to physiology

Dr Michael Schmuker, Neuroinformatics & Theoretical Neuroscience, Freie Universität Berlin.

Unilever Lecture Theatre.

Tuesday 25 March 2014, 14:15-15:45

MRC LMB Seminar Series

microRNAs, circular RNAs, and micropeptides

Professor Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 24 March 2014, 15:00-16:15

MRC LMB Seminar Series

Type VI Secretion System: structure, function and dynamics of a multicomponent nanomachine that is evolutionarily related to a contractile phage tail

Marek Basler, University of Basel.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 26 February 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Small Angle X-ray Scattering: sample preparation, data collection, and data analysis.

Dr Meindert Lamers, MRC-LMB, Cambridge, U.K.

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 February 2014, 10:15-11:15

Centre for Molecular Science Informatics

Protein-Ligand Binding by Free Energy Simulations: Issues, Successes and Failures

Please note the change of date, one week earlier than originally planned

Professor Jonathan Essex, University of Southampton.

Unilever Lecture Theatre.

Tuesday 25 February 2014, 14:15-15:45

Structural Biology group talks at Biochemistry

The extracellular lysine residues of in vitro folded neuropeptide receptor type 2 interacting with its ligand observed by > NMR spectroscopy

Dr Sandra Berndt, Nietlispach lab, Biochemistry Dept.

Department of Biochemistry, Sanger building, Seminar Room.

Wednesday 12 February 2014, 10:15-10:45

Structural Biology group talks at Biochemistry

Targeting Ubiquitin chains with Deubiquitinases

Dr Yu Ye, Klenerman lab, Chemistry Dept.

Department of Biochemistry, Sanger building, Seminar Room.

Wednesday 12 February 2014, 10:15-10:45

MRC LMB Seminar Series

Lighting up RNA Interactions in Living Cells

David Tollervey, WTCCB, University of Edinburgh.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 10 February 2014, 14:00-15:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach

Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd..

Biochemistry Seminar Room, Sanger Building.

Wednesday 05 February 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Paula de Fonseca - LMB.

Biochemistry Seminar Room, Sanger Building.

Tuesday 28 January 2014, 10:15-11:30

MRC LMB Seminar Series

Feldberg Prize Lecture: The mitochondrial machinery for transport and assembly of proteins

Klaus Pfanner, University of Freiburg.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 23 January 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using evolutionary sequence variation to make inferences about protein structure and function

Lucy J. Colwell, Department of Chemistry, University of Cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 22 January 2014, 10:15-11:15

MRC LMB Seminar Series

Systematic cell biology - Moving beyond text-book schemes

Maya Schuldiner, The Weizmann Insitute of Science.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 09 January 2014, 14:00-15:00

MRC LMB Seminar Series

GPCRs: From thermostabilisation to X-ray structures and Drug discovery

Fiona Marshall, Heptares Therapeutics.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 12 December 2013, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein-Protein Interaction Networks and Diseases

Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK .

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Analysis of allosteric communication and functional local motions using a Structural Alphabe

Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK .

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Chirality as a crossroad of chemistry and biology

Professor Reiko KURODA, Tokyo University of Science (Japan).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 November 2013, 10:15-11:15

MRC LMB Seminar Series

Brain Power: Where does it come from and how is it used?

Professor David Attwell, University College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 November 2013, 17:00-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Shaoxia Chen, MRC-LMB, cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 06 November 2013, 10:15-11:15

MRC LMB Seminar Series

John Kendrew Lecture 2013: Noncoding RNAs: with a viral twist

Joan Steitz, Yale University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 01 November 2013, 16:15-18:00

MRC LMB Seminar Series

Embracing Complexity: A Drosophila Approach To Cancer Therapeutics

Ross Cagan, Mt. Sinai School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 31 October 2013, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Evolution & dynamics of protein complexes

Sarah Teichmann, Wellcome Trust Sanger Institute.

Biochemistry Seminar Room, Sanger Building.

Wednesday 30 October 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystallisation and structure of respiratory complex I, a giant molecular proton pump

Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 23 October 2013, 10:15-11:15

Centre for Molecular Science Informatics

Protein-Ligand Binding by Free Energy Simulations: Issues, Successes and Failures

We regret that due to illness this talk has been cancelled

Professor Jonathan Essex, University of Southampton.

Unilever Lecture Theatre.

Tuesday 15 October 2013, 12:00-13:30

MRC LMB Seminar Series

Can structural studies of intact viruses really be useful in the search for better vaccines and antivirals?

David Stuart, University of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 October 2013, 16:15-18:00

Centre for Molecular Science Informatics

"Global Protein Structural Analysis for Drug Discovery"

Dr Krishna Bulusu, from the Institute of Cancer Research (ICR).

Todd Hamied Room, Department of Chemistry.

Tuesday 08 October 2013, 14:15-15:45

MRC LMB Seminar Series

Conformational Conversion in Amyloid Assembly

Sheena Radford, University of Leeds.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 03 October 2013, 16:15-18:00

MRC LMB Seminar Series

Milstein Lecture 2013: Sorting out protein traffic: Ubiquitin-mediated endocytosis and a membrane protien’s final ESCRT

Scott Emr, Cornell University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 September 2013, 16:15-18:00

MRC LMB Seminar Series

Innate Immune Sensing and Signaling of Cytosolic DNA and RNA

Zhijan 'James' Chen, University of Texas Southwestern Medical Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 24 September 2013, 16:15-18:00

MRC LMB Seminar Series

Long-distance organelle transport in the neuron: mechanisms of motor engagement and motor coordination

Erika Holzbaur, University of Pennyslvania.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 05 September 2013, 16:15-18:00

MRC LMB Seminar Series

The Evolutionary 'Design' of Proteins

Rama Ranganathan, UT Southwestern Medical Centre.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 04 September 2013, 11:00-12:00

Centre for Molecular Science Informatics

On the importance of the COSMO polarization charge density for the quantification of molecular interactions in liquid phases

Prof. Dr. Andreas Klamt, COSMOlogic GmbH & Co. KG.

Unilever Lecture Theatre.

Wednesday 28 August 2013, 15:00-16:30

MRC LMB Seminar Series

Watching Individual Proteins Working on Single Molecules of DNA: from Biophysics to Cancer

Steve Kowalczykowski, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 09 August 2013, 16:15-18:00

MRC LMB Seminar Series

Biological insights from cryo-EM studies of complex macromolecular assemblies in transcription initiation and microtubule dynamics

Eva Nogales, HHMI University of California Berkely.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 24 July 2013, 16:15-18:00

MRC LMB Seminar Series

The impact of systemic inflammation on the brain in health and disease

Hugh Perry, University of Southampton.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 June 2013, 16:15-18:00

MRC LMB Seminar Series

Intrinsic biophysical diversity and connectivity of neuronal circuits

Troy Margrie, NIMR.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 11 June 2013, 17:00-18:00

Centre for Molecular Science Informatics

Approaching protein dynamics in the post-genome era

Professor Modesto Orozco, Dept. Biochemistry & Molecular Biology, University of Barcelona .

Unilever Lecture Theatre.

Tuesday 11 June 2013, 14:15-15:30

MRC LMB Seminar Series

Direct Selection for Antibodies that Control Cell Fates from Intracellular Combinatorial Antibody Libraries

Professor Richard Lerner, The Scripps Research Institute, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 05 June 2013, 12:00-13:00

Centre for Molecular Science Informatics

"Molecular Dynamics Simulations of the Influenza Virus Envelope: Complex Interplay between Membrane Proteins and Lipid Domains"

Dr Daniel Parton, Sloan Kettering Institute, New York.

Unilever Lecture Theatre.

Wednesday 29 May 2013, 14:15-15:30

Centre for Molecular Science Informatics

Calculations on Tunneling by Carbon Tell Experimentalists Where to Look and What to Look For

Professor Wes Borden, Unversity of Texas.

Unilever Lecture Theatre.

Tuesday 28 May 2013, 14:15-15:30

Centre for Molecular Science Informatics

Why Does Cyclobutane-1,2,3,4-tetraone Have a Triplet Ground State?

A TMI RIG Presentation

Professor Wes Borden, Unversity of Texas.

Pfizer Lecture Theatre, Department of Chemistry.

Wednesday 22 May 2013, 14:15-15:30

Centre for Molecular Science Informatics

"Using computational methods to aid our understanding of ionotropic glutamate receptors at the molecular level"

Dr Phil Biggin, Department of Biochemistry, University of Oxford.

Unilever Lecture Theatre.

Tuesday 21 May 2013, 14:15-15:30

MRC LMB Seminar Series

Cytoskeletal Control of Leukocyte Chemotaxis

Michael Sixt, IST Austria.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 13 May 2013, 16:15-18:00

MRC LMB Seminar Series

Selective autophagy: when being picky pays of

Ana-Maria Cuervo, Albert Einstein College of Medicine .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 02 May 2013, 16:15-18:00

MRC LMB Seminar Series

Max Perutz Lecture: Five ways that viruses use to enter the animal cell

Professor Ari Helenius, ETH Zurich, Switzerland.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 30 April 2013, 14:30-15:30

Centre for Molecular Science Informatics

Enzyme dynamics, conformations and catalysis

Professor Adrian Mulholland, Centre for Computational Chemistry, Univeristy of Bristol.

Unilever Lecture Theatre.

Tuesday 30 April 2013, 14:15-15:30

MRC LMB Seminar Series

Machinery for making coated vesicles

Margaret Scott Robinson, CIMR.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 16 April 2013, 16:15-18:00

MRC LMB Seminar Series

The genetics of individuals: why would a mutation kill me, but not you?

Ben Lehner, CRG Barcelona.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 09 April 2013, 15:00-16:00

MRC LMB Seminar Series

The mammalian circadian timing system: how the brain communicates with the periphery

Ueli Schibler, University of Geneva.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 27 March 2013, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry

Dr John Burke, LMB, Cambridge U.K.

Perham's seminar room.

Wednesday 27 March 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Open Source Drug Discovery:  Developing a Systems Level Translational Platform for Neglected Diseases

Prof. Samir K. Brahmachari, Founder Director, Institute of Genomics and Integrative Biology,  Director General, Council of Scientific & Industrial Research,  Delhi, India.

Biochemistry Lecture Theatre, Sanger Building.

Friday 22 March 2013, 13:00-14:00

Structural Biology group talks at Biochemistry

Come and meet the Monster: a work in progress on human Rad51 oligomeric structure ("the Monster") and its potential relevance for DNA Repair and drug design.

Tommaso Moschetti (Hyvonen Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 19 March 2013, 16:00-17:00

Structural Biology group talks at Biochemistry

Single molecule imaging reveals that CENP-A deposition occurs during G2 in fission yeast

David Lando (Laue Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 19 March 2013, 16:00-17:00

Structural Biology group talks at Biochemistry

New Developments at Diamond Light Source and the use of Free Electron Lasers in structural biology

Steven Hardwick & Jarrod Voss (Luisi Group) .

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 05 March 2013, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

PHASER workshop

Airlie McCoy, CIMR, University of Cambridge.

Perham's seminar room.

Wednesday 27 February 2013, 10:15-11:15

Centre for Molecular Science Informatics

“Data Driven Molecular Design & Discovery”

Dr Scott Lusher, Netherlands eScience Centre.

Unilever Lecture Theatre.

Thursday 21 February 2013, 11:00-12:00

Structural Biology group talks at Biochemistry

Assembly of a protein-RNA bacterial suicide complex

Francesca Short (Salmond Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 19 February 2013, 16:00-17:00

Structural Biology group talks at Biochemistry

Mechanisms of extracellular regulation of TGFβ superfamily: protein engineering and interaction analysis

Cat Donaldson (Hyvonen Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 19 February 2013, 16:00-17:00

Centre for Molecular Science Informatics

"Thinking (and looking) out of the box - new tricks for molecular simulation and visualization"

Dr Marc Baaden, Institut de Biologie Physico-Chimque, Paris.

Unilever Lecture Theatre.

Tuesday 19 February 2013, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

OPPF-UK: a national resource centre for protein production.

Dr Louise Bird, OPPF, UK.

Perham's seminar room.

Wednesday 13 February 2013, 10:15-11:15

Structural Biology group talks at Biochemistry

Snaphshots of Membrane Proteins at Work

Simone Weyand (Lummis Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 05 February 2013, 16:00-17:00

Structural Biology group talks at Biochemistry

The role of the acidic tail in HMGB proteins: a combined NMR and SAXS approach

Katherine Stott (Thomas Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 05 February 2013, 16:00-17:00

Structural Biology group talks at Biochemistry

Specificity in the Ubiquitin System

David Komander (LMB).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 22 January 2013, 16:00-17:00

MRC LMB Seminar Series

Assembly and Dynamics of Uber Complex RNPs

Melissa Moore, University of Massachusetts Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 03 December 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

Dissecting Fragment-Based Lead Discovery at the von Hippel Lindau protein:Hypoxia Inducible Factor-1alpha Interface

Inge van Molle (Ciulli Group, Chemistry).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 27 November 2012, 16:00-17:00

Structural Biology group talks at Biochemistry

The Discovery of Novel Sialidase Inhibitors

Paul Brear (Hyvonen Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 27 November 2012, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction antagonists

Carlos Carmachio.

Perham's seminar room.

Wednesday 21 November 2012, 10:15-11:15

Structural Biology group talks at Biochemistry

Catalytic Promiscuity in the Alkaline Phosphatase Superfamily

Bert van Loo (FH Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 13 November 2012, 15:45-16:45

Structural Biology group talks at Biochemistry

Label-free Study of Chromatin Architecture in Living Organisms using Stimulated Raman Scattering Microscopy

Srinjan Basu (EDL Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 13 November 2012, 15:45-16:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks

Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre.

Perham's seminar room.

Wednesday 07 November 2012, 10:15-11:15

Structural Biology group talks at Biochemistry

Replication Initiation: Focus on the Components of the Pre-initiation Complex

Oleg Kovalevskiy (Zegerman Group, Gurdon).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 30 October 2012, 15:45-16:45

Structural Biology group talks at Biochemistry

The Structural Basis of Z Alpha-1-antitrypsin Deficiency

Tim Sendall (HM/DO Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 30 October 2012, 15:45-16:45

Centre for Molecular Science Informatics

"The mechanisms of solute flux through membrane channels from multi-microsecond equilibrium simulations"

Dr Martin Ulmschneider, Dept. of Biological Sciences, Birkbeck College, University of London.

Unilever Lecture Theatre.

Tuesday 30 October 2012, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The importance of thermostability and its application to the structure determination of GPCRs

Dr Chris Tate, LMB.

Perham's seminar room.

Wednesday 24 October 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

X-ray diffraction data reduction: space group determination, scaling and intensity statistics

Dr Phil Evans, FRS, LMB.

Perham's seminar room.

Wednesday 10 October 2012, 10:15-11:15

Structural Biology group talks at Biochemistry

PHD Zinc Fingers in Chromatin-Associated Proteins

Cynthia Tallant-Blanco (Cuilli Group, Chemistry).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 09 October 2012, 15:45-16:45

Structural Biology group talks at Biochemistry

NMR Applications to Large Systems: Sensory Rhodopsin II, Membrane Mimics and Fast NMR

Mark Bostock (DN Group).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 09 October 2012, 15:45-16:45

Structural Biology group talks at Biochemistry

The Structures of Whole Chromosomes in Individual Cells

Tim Stevens (EDL Group).

Biochemistry Seminar Room, Sanger Building.

Tuesday 18 September 2012, 16:00-17:00

MRC LMB Seminar Series

New insights into the role of the chromatin associated factor ATRX

Doug Higgs, MRC Molecular Haematology Unit, Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 17 September 2012, 11:30-13:00

MRC LMB Seminar Series

Max Perutz Lecture 2012: Defective DNA strand break repair, genome instability and cancer

Steve West, CRUK LRI - Clare Hall.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 13 September 2012, 16:15-18:00

MRC LMB Seminar Series

Lgr5 Stem Cells in self-renewal and cancer

Joint lecture with CRI and MRC LMB

Hans Clevers, Hubrecht Institute.

Cambridge Research Institute.

Tuesday 11 September 2012, 13:00-14:30

Centre for Molecular Science Informatics

Successes and challenges in the prediction of P450 mediated drug metabolism

Professor Patrik Rydberg, University of Copenhagen, Department of Drug Design and Pharmacology.

Unilever Lecture Theatre.

Tuesday 04 September 2012, 14:00-15:30

MRC LMB Seminar Series

Normal and neoplastic stem cells

Irving Weissman, Stanford School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 11 July 2012, 16:15-18:00

Centre for Molecular Science Informatics

"Entropy and order parameters from ensembles generated by computer simulations"

Profressor Klaus Liedl, University of Innsbruck.

Unilever Lecture Theatre.

Wednesday 27 June 2012, 15:15-16:30

MRC LMB Seminar Series

Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

Fred Goldberg, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 22 June 2012, 16:15-18:00

Centre for Molecular Science Informatics

"Dynamics of Biomolecules: from the Glass Transition to Drug Design"

A joint Theory/UCC talk as part of the TMI Research Interest Group

Professor Jeremy C Smith, Oak Ridge National Laboratory.

Pfizer Lecture Theatre, Dept. of Chemistry.

Wednesday 20 June 2012, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Helen Saibil.

Perham's seminar room.

Wednesday 13 June 2012, 10:15-11:15

MRC LMB Seminar Series

Shedding light on Ubiquitin Modification in Cancer.

Vishva Dixit, Genentech.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 12 June 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

Crystal Structure of Folliculin Uncovers a HiDENN Function

Ravi Nookala (TLB Group).

Biochemistry Seminar Room, Sanger Building.

Tuesday 12 June 2012, 16:00-17:00

MRC LMB Seminar Series

The structural and mechanistic basis for Rab cycling and targeting

Roger Goody, MPI Dortmund.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 21 May 2012, 16:15-18:00

MRC LMB Seminar Series

Milstein Lecture 2012: How do we sense microbes? From LPS, TNF, and the TLRs.

Bruce Beutler, UT Southwestern Medical Centre.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 17 May 2012, 16:15-18:00

MRC LMB Seminar Series

Monitoring protein synthesis one codon at a time through ribosome profiling

Jonathan Weissman, Howard Hughes Medical Institute, UCSF.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 May 2012, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of chromosome segregation

Martin Singleton.

Perham's seminar room.

Wednesday 02 May 2012, 10:15-11:15

MRC LMB Seminar Series

Local Translation at the Synapse

Erin Schuman, Max Planck Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 30 April 2012, 16:15-18:00

MRC LMB Seminar Series

How end binding proteins recognise growing microtubule ends: from molecular structure to network functioning

Thomas Surrey, Cancer Research UK, London Research Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 April 2012, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

SAXS studies on biological molecules at Diamond Light Source

Inoue Katsuaki, DLS, UK.

Perham's seminar room.

Wednesday 25 April 2012, 10:15-11:15

MRC LMB Seminar Series

Molecular mechanisms of complement activation and regulation

Piet Gros, Utrecht University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 April 2012, 14:00-16:00

MRC LMB Seminar Series

Ubiquitin flips the anaphase switch

David Morgan, UCSF.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 13 April 2012, 16:15-18:00

MRC LMB Seminar Series

John Kendrew Lecture 2012: Harnessing actin dynamics for endocytic trafficking events

David Drubin, Berkeley.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 03 April 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

Structural studies of HAT1 and its binding partners

Ian Le Guillou (EDL).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 20 March 2012, 16:00-17:00

Structural Biology group talks at Biochemistry

Allosteric Regulation and Assembly of Glutamate Receptor Ion Channels.

Maxim Rossmann (MH).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 20 March 2012, 16:00-17:00

Structural Biology group talks at Biochemistry

David Lando Talk

David Lando (Laue Group).

Biochemistry Lecture Theatre, Sanger Building.

Monday 19 March 2012, 16:00-17:00

MRC LMB Seminar Series

A Chemicogenetic approach to DNA repair implicates TORC2 and actin in survival of DNA breaks

Susan Gasser, Friedrich Miescher Institute for Biomedical Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 12 March 2012, 16:15-18:00

MRC LMB Seminar Series

Disruptions on the Highways of Cell Communication

Dario Alessi, MRC Protein Phosphorylation Unit, University of Dundee.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 06 March 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

From protein interactions to gene expression distributions

Sarah Teichmann (LMB).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 06 March 2012, 16:00-17:00

MRC LMB Seminar Series

Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

James Rothman, Yale University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 21 February 2012, 11:30-18:00

MRC LMB Seminar Series

Crick Lecture 2012: Consequences of Aneuploidy

Angelika Amon, HHMI, MIT.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 15 February 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

Solid-State NMR Investigations of Membrane Bound Ras Proteins and Y2 G Protein-Coupled Receptors

Prof. Daniel Huster. Institute for Medical Physics and Biophysics, University of Leipzig.

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 14 February 2012, 16:00-17:00

MRC LMB Seminar Series

New concepts in host-pathogen interactions: lessons from Listeria

Pascale Cossart, Institute Pasteur, Paris.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 02 February 2012, 16:15-18:00

Centre for Molecular Science Informatics

Lessons from Yeast: Drug Uptake and Systems Biology

Dr Paul D Dobson, Department of Chemical & Biological Engineering, University of Sheffield.

Unilever Lecture Theatre.

Tuesday 31 January 2012, 14:00-15:30

Structural Biology group talks at Biochemistry

Structural Biology facilities - Updates and Discussion Session

Dima Chirgadze, Katherine Stott.

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 24 January 2012, 16:00-17:00

MRC LMB Seminar Series

Functions of Dynamin A, Myosin IB and WASH in phagolysosome biogenesis, and the Exocyst in kiss-and-run exocytosis in Dictyostelium

Thierry Soldati, University of Geneva.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 23 January 2012, 16:15-18:00

Structural Biology group talks at Biochemistry

A Study of the Human Primase: Initiator of DNA Replication

Mairi Kilkenny (LP).

Biochemistry Seminar Room, Sanger Building.

Tuesday 10 January 2012, 16:00-17:00

Structural Biology group talks at Biochemistry

Relating structure to function in natural surfactant proteins.

Steve Vance (RWB).

Biochemistry Seminar Room, Sanger Building.

Tuesday 10 January 2012, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Domain swapping in proteins

Dr Sowdhamini, National Centre for Biological Sciences (TIFR) UAS-GKVK Campus Bellary Road Bangalore 560 065 INDIA.

Perham's seminar room.

Wednesday 21 December 2011, 10:15-11:15

MRC LMB Seminar Series

Signaling through the ubiquitin system

Wade Harper, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 15 December 2011, 16:15-18:00

Journal Clubs

Journal Club

Heather (BL).

Seminar Room, Sanger Building.

Monday 12 December 2011, 10:55-11:15

Journal Clubs

Journal Club

Angela (TLB).

Seminar Room, Sanger Building.

Monday 12 December 2011, 10:35-10:55

Journal Clubs

Journal Club

Sandra (MH).

Seminar Room, Sanger Building.

Monday 12 December 2011, 10:15-10:35

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

To be confirmed

Dr Bissan Al-Lazikani, Computational Biology and Chemogenomics Institute of Cancer Research, U.K.

Perham's seminar room.

Wednesday 07 December 2011, 10:15-11:15

Structural Biology group talks at Biochemistry

FKBP - a structure without a cause?

Christian Edlich (EDL).

Biochemistry Seminar Room, Sanger Building.

Tuesday 06 December 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

Model interaction systems in the search for inhibitors of protein-protein interactions

Sandra Greive (MH).

Biochemistry Seminar Room, Sanger Building.

Tuesday 06 December 2011, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Low Resolution Crystallography

Dr Dima Chirgadze, Biochemistry Department, University of Cambridge.

Perham's seminar room.

Wednesday 30 November 2011, 10:15-11:15

Structural Biology group talks at Biochemistry

Zinc fingers reading signals

David Neuhaus (LMB).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 29 November 2011, 16:00-17:00

MRC LMB Seminar Series

Structural and Mechanistic Studies of the Anaphase Promoting Complex

David Barford, Institute of Cancer Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 24 November 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Making candy for signal transduction research - Adventures in Willy Wonka land

Prof Morten Grötli, Department of Chemistry, University of Gothenburg.

Perham's seminar room.

Thursday 24 November 2011, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Low resolution refinement tools in the program REFMAC

Dr Garib N Murshudov, LMB, MRC, Cambridge, U.K.

Perham's seminar room.

Wednesday 23 November 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions

Professor Monika Fuxreiter Institute of Enzymology, Budapest, HUNGARY and LMB, MRC, Cambridge, UK.

Perham's seminar room.

Wednesday 16 November 2011, 10:15-11:15

MRC LMB Seminar Series

The Evolution of Enzyme Mechanisms and Functional Diversity

Janet Thornton, EMBL-EBI.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 November 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

A Bayesian view on cryo-EM structure determination

Sjors Scheres (LMB).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 15 November 2011, 16:00-17:00

Journal Clubs

Journal Club

Cat (MH).

Seminar Room, Sanger Building.

Monday 14 November 2011, 10:55-11:15

Journal Clubs

Journal Club

Steven (BL).

Seminar Room, Sanger Building.

Monday 14 November 2011, 10:35-10:55

Journal Clubs

Journal Club

Ravi (TLB).

Seminar Room, Sanger Building.

Monday 14 November 2011, 10:15-10:35

Structural Biology group talks at Biochemistry

Structural and interaction studies of domain C0 of cardiac Myosin Binding Protein C (cMyBP-C) by NMR spectroscopy

Joyce Ratti (NM).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 01 November 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

At the Frontier of Membrane Protein Crystallography: The Structure of Yeast Aquaporin to 0.9 Å at Cryogenic and 1.3 Å at Room Temperature.

Gerhard Fischer (University of Gothenburg, Sweden).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 01 November 2011, 16:00-17:00

MRC LMB Seminar Series

Structural Studies on the Regulation of Protein Kinases: EGFR and CamK-II

John Kuriyan, HHMI, University of California, Berkeley.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 31 October 2011, 16:15-18:00

MRC LMB Seminar Series

Neuronal plasticity: from synapses to the axon initial segment

Juan Burrone, Kings College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 28 October 2011, 16:15-18:00

MRC LMB Seminar Series

DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innate immunity

Geoffrey Smith, Department of Pathology Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 06 October 2011, 16:15-18:00

MRC LMB Seminar Series

mRNA-tRNA translocation intermediates by cryo-EM: a look at the free-energy landscape from a single sample.

Joachim Frank, Columbia University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 30 September 2011, 16:15-18:00

Centre for Molecular Science Informatics

"New Developments in Semiempirical MO Theory for Drug and Materials Design"

This Lecture is part of Professor Clark's MGMS Lecture tour

Professor Tim Clark, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

Pfizer Lecture Theatre, Dept. of Chemistry.

Thursday 22 September 2011, 14:00-15:30

MRC LMB Seminar Series

Molecular and cellular mechanisms for memory allocation in neuronal networks

Alcino Silva, UCLA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 16 September 2011, 16:15-18:00

MRC LMB Seminar Series

Genetic dissection of emotion circuits in flies and mice - Francis Crick Lecture 2011

Dr David Anderson, California Institute of Technology, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 09 September 2011, 16:00-18:00

Structural Biology group talks at Biochemistry

Most recent development in crystalisation optimization and shotgun diffraction

Professor Seth Fraden, Brandeis University,Waltham, MA, USA.

Seminar Room, Sanger Building.

Friday 29 July 2011, 14:00-15:00

Structural Biology group talks at Biochemistry

Snapshots of the membrane protein Mhp1 at work

Dr Simone Weyand, Imperial College.

Seminar Room, Sanger Building.

Friday 29 July 2011, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural complexomics of eukaryotic gene expression.

Dr Imre Berger, EMBL, Grenoble, France.

Seminar Room, Sanger Building.

Wednesday 27 July 2011, 10:15-11:00

MRC LMB Seminar Series

Self-assembled DNA-nanostructure tools for molecular biophysics

William Shih, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 25 July 2011, 16:15-18:00

MRC LMB Seminar Series

PDBe - Bringing Structure to Biology

Gerard Kleywegt, EMBL-EBI.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 14 July 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Receptor-based Drug Discovery

Dr Jiye Shi, UCB Celltech.

Seminar Room, Sanger Building.

Wednesday 13 July 2011, 10:15-11:00

MRC LMB Seminar Series

Tuberculosis Treatment Dicta from the Zebrafish

Lalita Ramakrishnan, University of Washington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 July 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing protein-ligand recognition mechanisms with isothermal titration calorimetry

Dr Mark Williams. Birkbeck College.

Room 2, Stem Cell Research Centre.

Wednesday 06 July 2011, 11:00-12:00

Structural Biology group talks at Biochemistry

"Structural Basis of the Regulation of Chromosome Segregation and Mitosis Progression"

Victor Bolanos-Garcia (TLB group).

Seminar Room, Sanger Building.

Tuesday 28 June 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"A new structural genomics: the structures of whole chromosomes"

Tim Stevens (EDL).

Seminar Room, Sanger Building.

Tuesday 28 June 2011, 16:00-17:00

MRC LMB Seminar Series

Autoantibodies against NMDA receptors and other neuronal targets: the widening spectrum of antibody-mediated CNS disorders

Angela Vincent, University of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 22 June 2011, 14:30-16:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal dehydration: Experimental design with a home source and at the synchroton

Dr Juan Sanchez Weatherby: Diamond, UK.

Seminar Room, Sanger Building.

Wednesday 22 June 2011, 10:15-11:00

Structural Biology group talks at Biochemistry

"Structure of a motor-driven restriction-modification enzyme bound to its target DNA"

Saikrishnan Kayarat (LMB).

Seminar Room, Sanger Building.

Tuesday 21 June 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Structure-function studies of the archaeal HR nuclease NurA"

Neil Rzechorzek (LP group).

Seminar Room, Sanger Building.

Tuesday 21 June 2011, 16:00-17:00

MRC LMB Seminar Series

Exploring and exploiting chromosome repair and segregation mechanisms in cancer

Ashok Venkitaraman, MRC Cancer Cell Unit.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 16 June 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past.

Dr Andreas Bender, Unilever Centre, Cambridge.

Seminar Room, Sanger Building.

Wednesday 15 June 2011, 10:15-11:00

Structural Biology group talks at Biochemistry

Determining structures with NMR - the CcpNmr Analysis program

Rasmus Fogh (EDL Group).

Seminar Room, Sanger Building.

Tuesday 07 June 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"DNA Polymerase alpha at work: Understanding the Mechanism"

Rajika Perera (LP group).

Seminar Room, Sanger Building.

Tuesday 07 June 2011, 16:00-17:00

MRC LMB Seminar Series

Visualizing vesicle and virus budding by electron microscopy

John Briggs, EMBL.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 01 June 2011, 11:30-13:15

MRC LMB Seminar Series

Genetic Architecture of Leukaemia

Mel Greaves, Institute of Cancer Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 May 2011, 16:15-18:00

Centre for Molecular Science Informatics

Exploring free-energy landscapes

Professor Daan Frenkel FRS, Cambridge University Centre for Computational Chemistry, Department of Chemistry.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Thursday 19 May 2011, 15:30-16:30

Centre for Molecular Science Informatics

The power of coarse-graining in biomolecular simulations

Professor Siewert-Jan Marrink, Groningen Biomolecular Sciences and Biotechnology Institute.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Thursday 19 May 2011, 14:00-15:30

Centre for Molecular Science Informatics

"Manipulating dynamics: Galilean-invariant friction and stochastic thermostats"

Professor Herman Berendsen, Groningen Biomolecular Sciences and Biotechnology Institute.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Wednesday 18 May 2011, 14:00-15:30

MRC LMB Seminar Series

Delivery Boy to Reporter: Unusual DNA’s journey through a worm-whole

Yamuna Krishnan, National Centre for Biological Sciences Bangalore.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 17 May 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

"Chromatin Assembly Factor 1: Working with protein complexes"

Nikki Royle (EDL group).

Seminar Room, Sanger Building.

Tuesday 17 May 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Structural studies of non-coding RNA mediated gene silencing in E. coli"

Kasia Bandyra (BL group).

Seminar Room, Sanger Building.

Tuesday 17 May 2011, 16:00-17:00

Centre for Molecular Science Informatics

"Molecular dynamics beyond molecules: principles for coarse-graining"

Professor Herman Berendsen, Groningen Biomolecular Sciences and Biotechnology Institute.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 17 May 2011, 14:00-15:30

MRC LMB Seminar Series

A primer on DNA origami and why molecular biologists might care

Hendrik Dietz, TU Munich.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 12 May 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

"Mimicking the membrane; micelles, bicelles and nanodiscs"

Mark Bostock (DN group).

Seminar Room, Sanger Building.

Tuesday 10 May 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Do very similar proteins fold in very similar ways?"

Tim Sharpe (MH group).

Seminar Room, Sanger Building.

Tuesday 10 May 2011, 16:00-17:00

MRC LMB Seminar Series

Genome-wide analysis of AID activity and AID-mediated translocations in B lymphocytes

Rafael Casellas, NIH.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 06 May 2011, 16:15-18:00

MRC LMB Seminar Series

Feldberg Prize Lecture: Biogenesis of iron-sulfur proteins in eukaryotes

Professor Roland Lill, Philipps University Marburg, Germany.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 15 April 2011, 16:15-18:00

MRC LMB Seminar Series

Controlling Recombination

Simon Boulton, CRUK Clare Hall Laboratories.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 14 April 2011, 16:15-18:00

MRC LMB Seminar Series

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Anne-Claude Gavin, EMBL.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 12 April 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

"Using high throughput simulation to understand signalling processes"

Benjamin Hall (University of Oxford).

Seminar Room, Sanger Building.

Tuesday 12 April 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Structure of RLIP76’s GTPase activating (GAP) and Ral binding domains (RBD) in solution"

Karthik Rajasekar (HRM-DO group).

Seminar Room, Sanger Building.

Tuesday 12 April 2011, 16:00-17:00

MRC LMB Seminar Series

Milstein Lecture 2011: How the endoplasmic reticulum gets into shape

Tom Rapoport, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 April 2011, 16:15-18:00

MRC LMB Seminar Series

The Chemical Biology of Large-Scale Transcriptome Analysis

Kevin Weeks, University of North Carolina.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 06 April 2011, 11:30-13:15

MRC LMB Seminar Series

The Cellular Basis for the Cancer-Related Phenomena of Immune Suppression and Cachexia

Doug Fearon.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 31 March 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

"Super-resolution imaging in pombe"

David Lando (EDL Group).

Seminar Room, Sanger Building.

Tuesday 29 March 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Structural studies of a human non-homologous end-joing protein complex: DNA ligaseIV/XRCC4"

Takashi Ochi (TLB group).

Seminar Room, Sanger Building.

Tuesday 29 March 2011, 16:00-17:00

MRC LMB Seminar Series

The Female Side of Fertilization: Crystal Structure of Vertebrate Sperm Receptor ZP3

Luca Jovine, Karolinska Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 28 March 2011, 16:15-18:00

MRC LMB Seminar Series

The Structural Basis of Ubiquitin Signalling

Cynthia Wolberger, Johns Hopkins University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 25 March 2011, 16:15-18:00

MRC LMB Seminar Series

Repeat Proteins:Versatile frameworks for understanding and engineering protein structure and function

Lynne Regan, Yale University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 21 March 2011, 16:15-18:00

Journal Clubs

Journal Club

Daniela (BL).

Seminar Room, Sanger Building.

Monday 21 March 2011, 10:55-11:15

Journal Clubs

Journal Club

May (MH).

Seminar Room, Sanger Building.

Monday 21 March 2011, 10:35-10:55

Journal Clubs

Journal Club

Kasia (BL).

Seminar Room, Sanger Building.

Monday 21 March 2011, 10:15-10:35

MRC LMB Seminar Series

Non-classical means for regulating small G-proteins

Shehab Ismail, Max Planck Institute Dortmund.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 17 March 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

"Segmental labelling approaches for multi-domain proteins"

Bill Broadhurst (RWB group).

Seminar Room, Sanger Building.

Tuesday 15 March 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"New dimensions in the study of protein complexes using mass spectrometry"

Dijana Matak-Vinkovic (Dept. Chemistry).

Seminar Room, Sanger Building.

Tuesday 15 March 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"The structural studies of PHD+CXXC domain"

Buyu Li (EDL group).

Seminar Room, Sanger Building.

Tuesday 08 March 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Fragment-based drug discovery on the MET receptor"

Anja Winter (TLB group).

Seminar Room, Sanger Building.

Tuesday 08 March 2011, 16:00-17:00

Centre for Molecular Science Informatics

"Bioactivity Mapping of Chemical Space"

Dr Jordi Mestres, IMIM, Barcelona Biomedical Reseach Park.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 08 March 2011, 14:15-15:30

Journal Clubs

Journal Club

Takashi (TLB).

Seminar Room, Sanger Building.

Monday 28 February 2011, 10:55-11:15

Journal Clubs

Journal Club

Sachin (TLB).

Seminar Room, Sanger Building.

Monday 28 February 2011, 10:35-10:55

Journal Clubs

Journal Club

Alicia (TLB).

Seminar Room, Sanger Building.

Monday 28 February 2011, 10:15-10:35

Centre for Molecular Science Informatics

Neurotransmitter transporters: from ligand-based to systems chemical biology approaches

Professor Olivier Taboureau, Center for Biological Sequence Analysis, Technical University of Denmark.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 22 February 2011, 14:15-15:30

MRC LMB Seminar Series

Accuracy of codon reading by transfer RNAs

Måns Ehrenberg.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 18 February 2011, 11:30-13:15

MRC LMB Seminar Series

Transport mechanism and membrane interactions of the cation pumps

Poul Nissen, Aarhus University, Denmark.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 17 February 2011, 16:15-18:00

MRC LMB Seminar Series

Pre- and postsynaptic NMDA receptors in neocortical synaptic plasticity

Ole Paulsen, Department of Physiology, University of Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 February 2011, 16:15-18:00

MRC LMB Seminar Series

Transcription and R-loops as a source of genome instability

Andrés Aguilera, University of Seville.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 08 February 2011, 16:15-18:00

Centre for Molecular Science Informatics

Toxicity from Predicting Chemistry - Categories, Read-Across and Integrated Testing Strategies

Professor Mark Cronin, Liverpool John Moores University.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 08 February 2011, 14:15-15:30

MRC LMB Seminar Series

In vitro and in vivo single molecule studies of chromosome replication and segregation

David Sherratt, University of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 07 February 2011, 16:15-18:00

MRC LMB Seminar Series

Genetic approaches to understand and manipulate retinal circuit function

Botond Roska, Friedrich Miescher Institute for Biomedical Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 03 February 2011, 16:15-18:00

Structural Biology group talks at Biochemistry

Super-resolution imaging in pombe

David Lando (EDL group).

Seminar Room, Sanger Building.

Tuesday 01 February 2011, 16:00-17:00

Structural Biology group talks at Biochemistry

"Structural Studies Of Innate Immune Response"

Eugene Valkov (MH group).

Seminar Room, Sanger Building.

Tuesday 01 February 2011, 16:00-17:00

MRC LMB Seminar Series

Off-the-shelf models of chromosomal translocations and using antibody fragments as cancer drug surrogates

Terry Rabbitts, Leeds Institute of Molecular Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 31 January 2011, 16:15-18:00

Journal Clubs

Journal Club

Sandra (MH).

Seminar Room, Sanger Building.

Monday 31 January 2011, 10:55-11:15

Journal Clubs

Journal Club

Jarrod (BL).

Seminar Room, Sanger Building.

Monday 31 January 2011, 10:35-10:55

Journal Clubs

Journal Club

Xue (BL).

Seminar Room, Sanger Building.

Monday 31 January 2011, 10:15-10:35

MRC LMB Seminar Series

Crystal structures of bacterial and yeast ribosomes

Marat Yusupov, Illkirch, France.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Drug Protein Interaction Databases

Adrian Schreyer, Alicia Higueruelo, Will Pitt.

Seminar Room, Sanger Building.

Wednesday 26 January 2011, 10:15-11:00

MRC LMB Seminar Series

Interactions of Cancer Stem Cells with their Niches are Essential for Breast Cancer Metastasis

Dr Joerg Huelsken, Swiss Federal Univerity of Technology, Lausanne, Switzerland.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 25 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The Ghosts of PDBe Past, Present  and Yet to Come

Dr Gerard Kleywegt, PDB Europe, EBI, Hinxton.

Seminar Room, Sanger Building.

Wednesday 12 January 2011, 10:15-11:00

MRC LMB Seminar Series

The mechanism of retroviral DNA integration through X-ray structures of its key intermediates

Peter Cherepanov, Faculty of Medicine, Imperial College.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 11 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

i-SITE: An energetic approach to predict ligand-binding site on protein surface

Dr Mizuki Morita, Laboratory of Bioinformatics, National Institute of Biomedical Innovation (NIBIO), Japan.

Seminar Room, Sanger Building.

Monday 10 January 2011, 11:30-12:00

MRC LMB Seminar Series

Structural biology of bacterial secretion systems

Gabriel Waksman.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 13 December 2010, 16:15-18:00

MRC LMB Seminar Series

Protein folding homeostasis and prion-like propagation of protein aggregation in neurodegenerative disease

Ron Kopito, Stanford University, CA USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 10 December 2010, 14:15-16:00

Structural Biology group talks at Biochemistry

Modular Protein Architecture, Cooperativity and Complexity in Cell Regulation

Speaker to be confirmed.

Seminar Room, Sanger Building.

Friday 10 December 2010, 12:00-13:00

MRC LMB Seminar Series

Structural insights into the process of co-translational targeting of membrane proteins and translation initiation in eukaryotes

Nenad Ban.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 06 December 2010, 16:15-18:00

MRC LMB Seminar Series

Femtosecond Membrane-Protein Nanodiffraction using a Hard X-Ray Laser

John Spence, Arizona State University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 23 November 2010, 16:15-18:00

Centre for Molecular Science Informatics

"Visualising and Predicting Organic Reactivity"

Dr Scott L Cockroft, Lecturer in Organic Chemistry, University of Edinburgh.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 23 November 2010, 14:15-15:30

MRC LMB Seminar Series

Dehydrated but unharmed? – the mass spectrometry of protein complexes

Professor Carol Robinson, Department of Chemistry, Oxford University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 22 November 2010, 16:15-18:00

Journal Clubs

Journal Club

Alicia (TLB).

Seminar Room, Sanger Building.

Monday 22 November 2010, 10:55-11:15

Journal Clubs

Journal Club

Anja (TLB).

Seminar Room, Sanger Building.

Monday 22 November 2010, 10:35-10:55

Journal Clubs

Journal Club

Zbyszek (BL).

Seminar Room, Sanger Building.

Monday 22 November 2010, 10:15-10:35

MRC LMB Seminar Series

Deconstructin oncogenesis and tumour suppression to find the best cancer drug targets

Gerard Evan, Department of Biochemistry, Unversity of Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 18 November 2010, 16:15-18:00

Centre for Molecular Science Informatics

“Accurate in-silico predictions can halve costs for experimental ADME Tox studies”

Dr Igor Tetko, Institute for Bioinformatics & Systems Biology, Neuherberg.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 16 November 2010, 14:15-15:15

MRC LMB Seminar Series

Regulation of microRNA biogenesis and function

Javier F Caceres, MRC Human Genetics Unit, Edinburgh.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 November 2010, 16:15-18:00

MRC LMB Seminar Series

Nucleocytoplasmic Transport Machinery and Pathways: Cell Cycle Regulation and Stress Response

Naoko Imamoto, Cellular Dynamics Laboratory, RIKEN ASI.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 November 2010, 14:00-16:00

Centre for Molecular Science Informatics

'“Multi-Scale Methods for the Investigation of Biological Structures and Processes”

Professor Marcus Elstner, Karlsruhe Institute of Technology.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 09 November 2010, 14:15-15:30

MRC LMB Seminar Series

Mitosis and Meiosis in live mammalian cells: From genome wide RNAi profiling to homologous chromosome segregation

Jan Ellenberg, EMBL, Heidelberg, Germany.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 November 2010, 14:15-16:00

Journal Clubs

Journal Club

Will (TLB).

Seminar Room, Sanger Building.

Monday 01 November 2010, 10:55-11:15

Journal Clubs

Journal Club

Michal (TLB).

Seminar Room, Sanger Building.

Monday 01 November 2010, 10:35-10:55

Journal Clubs

Journal Club

Tim (MH).

Seminar Room, Sanger Building.

Monday 01 November 2010, 10:15-10:35

Centre for Molecular Science Informatics

Exploring chemico-biological interactions using connectivity mapping

Dr Timothy Gant, MRC Toxicology Unit, University of Leicester.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 26 October 2010, 14:15-15:30

MRC LMB Seminar Series

Ion channels: Structure, modulation, and unconventional approaches

Dan Minor, University of California, San Francisco, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 25 October 2010, 16:15-18:00

Centre for Molecular Science Informatics

The bacterial outer membrane: capturing the details with molecular dynamics simulations

Dr Syma Khalid, School of Chemistry, University of Southampton.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Tuesday 19 October 2010, 14:15-15:30

Centre for Molecular Science Informatics

Application of Informatics within Unilever

Dr Ian Stott, Informatics & Maths Leader, Unilever R & D, Port Sunlight.

Todd Hamied Room, Dept. of Chemistry.

Wednesday 13 October 2010, 14:15-15:30

MRC LMB Seminar Series

Role of intrinsic Flexibility in Protein Regulatory Mechanisms

Richard Kriwacki, St Jude's Children's Research Hospital, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 October 2010, 16:15-18:00

MRC LMB Seminar Series

Small Molecules and Light as Tools for the Regulation of Biological Proceeses

Alex Deiters, North Carolina State University, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 29 September 2010, 16:15-18:00

MRC LMB Seminar Series

Connecting transcription with mRNA processing and chromatin

Steve Buratowski Harvard Medical School, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 21 September 2010, 16:15-18:00

Centre for Molecular Science Informatics

Past, present, and future of semiempirical methods

Dr James J P Stewart, Stewart Computational Chemistry, Colorado Springs, USA.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Thursday 16 September 2010, 14:15-15:30

MRC LMB Seminar Series

Autophagy: molecular machinery and role in diseases

Tamotsu Yoshimori Osaka University, Japan.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 13 September 2010, 12:15-13:30

MRC LMB Seminar Series

Gene Regulatory Network Guidance of Cellular Identity Choice: Stem Cells to T Cell

Ellen Rothenberg California Institute of Technology, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 13 September 2010, 11:00-12:00

MRC LMB Seminar Series

Assembly and function of K11-linked ubiquitin chains

Michael Rape, University of California, Berkeley, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 08 September 2010, 11:15-13:30

Centre for Molecular Science Informatics

Challenges in rational computer aided enzyme design

Professor Arieh Warshe, University of Southern California.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Thursday 02 September 2010, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The rational design of small-molecule Neuropilin-1 antagonists

Trevor Perrior, Research Director of Domainex.

Seminar Room, Sanger Building.

Wednesday 14 July 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Restraints on Protein Models from NMR Chemical Shifts

Rinaldo Wander Montalvao (Chemistry, Cambridge)..

Seminar Room, Sanger Building.

Wednesday 07 July 2010, 10:35-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Software for fragment linking and growing.

Nikolay Todorov (Molscape).

Seminar Room, Sanger Building.

Wednesday 07 July 2010, 10:15-11:00

Journal Clubs

Journal Club

Anja (TLB).

Seminar Room, Sanger Building.

Monday 05 July 2010, 10:55-11:15

Journal Clubs

Journal Club

Marcio (TLB).

Seminar Room, Sanger Building.

Monday 05 July 2010, 10:35-10:55

Journal Clubs

Journal Club

Jawon (TLB).

Seminar Room, Sanger Building.

Monday 05 July 2010, 10:15-10:35

Centre for Molecular Science Informatics

In Silico Drug discovery and molecular library focusing

Professor Amiram Goldblum, The Institute of Drug Research, Faculty of Medicine The Hebrew University of Jerusalem.

Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Wednesday 30 June 2010, 16:00-17:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Biacore for fragment screening

Catherine McDonnell, GE Healthcare.

Seminar Room, Sanger Building.

Wednesday 30 June 2010, 10:15-11:00

Structural Biology group talks at Biochemistry

Molecular recognition of chromatin: crystal structure of the chromatin factor RCC1 in complex with the nucleosome core particle

Professor Song Tan, Penn State University.

Lecture theatre, Sanger Building.

Tuesday 29 June 2010, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Off-site Targets: Predicting drug polypharmacology using ligand similarity ensembles.

Michael Keiser (UCSF).

Seminar Room, Sanger Building.

Wednesday 23 June 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targetting Protein-Protein Interactions: Synergies between NCEs and New Antibodies.

Dr Alastair Lawson (UCB- Celltech).

Seminar Room, Sanger Building.

Wednesday 16 June 2010, 10:15-11:00

Structural Biology group talks at Biochemistry

TICed off with protein transport into Plasmodium apicoplasts

Stephanie Glaser (MKH group).

Seminar Room, Sanger Building.

Tuesday 15 June 2010, 16:00-17:00

Structural Biology group talks at Biochemistry

Targeting tuberculosis: fragment-based approaces to drug discovery

Sachin Surade (TLB group).

Seminar Room, Sanger Building.

Tuesday 15 June 2010, 16:00-17:00

Journal Clubs

Journal Club

Leo (TLB).

Seminar Room, Sanger Building.

Monday 14 June 2010, 10:55-11:15

Journal Clubs

Journal Club

Kasia (BL).

Seminar Room, Sanger Building.

Monday 14 June 2010, 10:35-10:55

Journal Clubs

Journal Club

Yi-Chun (BL).

Seminar Room, Sanger Building.

Monday 14 June 2010, 10:15-10:35

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment-based drug discovery using X-ray crystallography.

Dr Anne Cleasby (Astex).

Seminar Room, Sanger Building.

Wednesday 02 June 2010, 10:15-11:00

Structural Biology group talks at Biochemistry

RNA processing machinery

Steven Hardwick (BL group).

Seminar Room, Sanger Building.

Tuesday 01 June 2010, 16:00-17:00

Structural Biology group talks at Biochemistry

Computational Structural Biology in a Pharma

Will Pitt (TLB group).

Seminar Room, Sanger Building.

Tuesday 01 June 2010, 16:00-17:00

A'-form RNA helices drive microtubule-based mRNA transport in Drosophila

Peter Lukavksy, MRC LMB.

Lecture theatre, Sanger Building.

Friday 28 May 2010, 11:00-12:00

MRC LMB Seminar Series

The genomic code for nucleosome positioning

Jon Widom, Department of Biochemistry, Northwestern University, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 20 May 2010, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Can machines understand the Scientific Literature?

Professor Peter Murray Rust (Unilever Centre, Chemistry, Cambridge).

Seminar Room, Sanger Building.

Wednesday 19 May 2010, 10:15-11:00

Structural Biology group talks at Biochemistry

Chaperoning histones - structural studies of the H3/H4/RbAp48 complex.

Marek Tyl (EDL group).

Seminar Room, Sanger Building.

Tuesday 18 May 2010, 16:00-17:00