LMB Seminar Series - Synthesis and hydrolysis of the gram-positive cell wall: revisiting old models with new data

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• David Rudner, Dept. of Microbiology and Immunobiology, Harvard Medical School
• Friday 03 May 2019, 11:00-12:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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Expansion of the bacterial cell wall is essential for growth but the mechanisms underlying the synthesis and hydrolysis of this three-dimensional meshwork remain poorly understood. A deeper understanding of these processes have the potential to define new vulnerabilities for therapeutic interventation. In my seminar, I will describe our discovery of a new and broadly conserved family of cell wall polymerases and our studies of two key cell wall hydrolases. With this information in hand, I will revisit and attempt to refine models championed by Koch and Doyle in the 1980s for how gram-positive bacteria remodel their cell wall during growth. Along the way, I will describe a novel signaling pathway that functions to maintain cell wall hydrolysis activity during growth..

This talk is part of the MRC LMB Seminar Series series.

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