Watching Individual Proteins Working on Single Molecules of DNA: from Biophysics to Cancer

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• Steve Kowalczykowski, University of California
• Friday 09 August 2013, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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We can now watch individual proteins acting on single molecules of DNA . Visualization is achieved by capturing a single DNA molecule with optical traps or by tethering to a glass surface. Proteins are visualized via fluorescent reporters, and molecules are manipulated using microfluidic flowcells. Using these approaches, we have imaged proteins functioning in the homology-directed repair of DNA breaks. We can image the search for DNA homology conducted by the RecA, the self-assembly of RecA and RAD51 on DNA , and the function of mediators such as RecFOR and BRCA2 .

This talk is part of the MRC LMB Seminar Series series.

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