Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

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• James Rothman, Yale University
• Tuesday 21 February 2012, 11:30-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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SNAR Es fuse cellular membranes, including synaptic vesicles with pre-synaptic plasma membranes to enable synaptic transmission. SNAR Es fuse membranes automatically, so a clamp is needed to prevent premature transmitter release, provided by the protein complexin. Recent studies have established the structural and biochemical mechanism of clamping by complexin involving a co-operative array of partly zippered SNAR Epins whose disolution can explain the syncronicity of transmitter release when the calcium sensor, synaptotagmin, perturbs the array.

This talk is part of the MRC LMB Seminar Series series.

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