University of Cambridge > > Centre for Molecular Science Informatics > "CADD & ENAC - A bad hand at Scrabble..?"

"CADD & ENAC - A bad hand at Scrabble..?"

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Cystic Fibrosis is a disease caused by genetic defects in the CFTR protein. The manifestation of those defects in the lung is a reduction in airway hydration producing a viscous mucal layer and ineffective mucocilliary clearance leading to pathogenic build up in the lungs. The Epithelial Sodium channel (ENaC) is instrumental in the osmotic gradients required for normal airway hydration and can serve as an alternative target for the mitigation of CF. The various approaches taken to develop inhibitors of ENaC will be described as well as the recent developments in the structural elucidation of the related family member ASIC .

This talk is part of the Centre for Molecular Science Informatics series.

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