"CADD & ENAC - A bad hand at Scrabble..?"

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• Dr Peter Hunt, Optibrium Ltd
• Tuesday 03 June 2014, 14:15-15:45
• Unilever Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Susan Begg.

Please note that the date of this seminar has been changed

Cystic Fibrosis is a disease caused by genetic defects in the CFTR protein. The manifestation of those defects in the lung is a reduction in airway hydration producing a viscous mucal layer and ineffective mucocilliary clearance leading to pathogenic build up in the lungs. The Epithelial Sodium channel (ENaC) is instrumental in the osmotic gradients required for normal airway hydration and can serve as an alternative target for the mitigation of CF. The various approaches taken to develop inhibitors of ENaC will be described as well as the recent developments in the structural elucidation of the related family member ASIC .

This talk is part of the Centre for Molecular Science Informatics series.

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• All Talks (aka the CURE list)
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• Cambridge Immunology
• Cambridge talks
• Centre for Molecular Science Informatics
• Department of Chemistry
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• Trust & Technology Initiative - interesting events
• Unilever Lecture Theatre, Department of Chemistry

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