The Female Side of Fertilization: Crystal Structure of Vertebrate Sperm Receptor ZP3

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• Luca Jovine, Karolinska Institute
• Monday 28 March 2011, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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Species-specific recognition between egg and sperm constitutes the initial, essential step of fertilization. Understanding this event would increase our knowledge of human infertility and could pave the way to the development of novel non-hormonal contraceptives; however, despite 30 years of very active research, its molecular basis remains unclear. I will present recent crystal structures of glycoprotein ZP3 , the component of the extracellular coat of eggs that acts as sperm receptor, and discuss what they tell us about the very first moments of conception.

This talk is part of the MRC LMB Seminar Series series.

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