Controlling Recombination

Add to your list(s) Download to your calendar using vCal

• Simon Boulton, CRUK Clare Hall Laboratories
• Thursday 14 April 2011, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Unscheduled or excessive homologous recombination (HR) can lead to gross chromosomal rearrangements characteristic of cancer cells, but the mechanisms that restrain HR remained poorly understood. We previously reported that rtel-1 mutant worms and RTEL1 depleted human cells exhibit hyper-recombination and sensitivity to DNA damaging agents. Biochemical studies revealed that RTEL1 promotes the disassembly of D loop recombination intermediates in vitro, which led us to propose that RTEL1 acts to counteract toxic recombination. More recently, we have shown that RTEL -1 is required for crossover interference and homeostasis and promotes non-crossover repair during C. elegans meiosis. Our recent efforts have focused on understanding the molecular basis of RTEL1 dysfunction in vertebrate cells; loss of Rtel1 results in reduced proliferative capacity, increased chromatid breaks, sensitivity to replication blocking lesions and telomere abnormalities. I will present our recent insights into the function of RTEL1 in controlling HR at telomeres and the activities that drive telomere dysfunction in its absence.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.