Species specific transcription in mice carrying a human chromosome

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• Duncan Odom (Cancer Research UK, CRI)
• Tuesday 07 October 2008, 13:00-14:00
• Lecture Theatre, Biochemistry, Department of (Sanger Building).

If you have a question about this talk, please contact Luca Pellegrini.

Homologous sets of transcription factors direct conserved tissue-specific gene expression, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from an aneuploid mouse strain carrying human chromosome 21 to determine on a chromosomal scale whether interspecies differences in transcriptional regulation are primarily directed by human genetic sequence or mouse nuclear environment. Virtually all transcription factor binding locations, landmarks of transcription initiation, and the resulting gene expression observed in human hepatocytes were recapitulated across the entire human chromosome 21 in the mouse hepatocyte nucleus. Thus, in homologous tissues, genetic sequence is largely responsible for directing transcriptional programs; interspecies differences in epigenetic machinery, cellular environment, and transcription factors themselves play secondary roles.

This talk is part of the Research Seminars - Department of Biochemistry 2008/09 series.

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