University of Cambridge > Talks.cam > MRC LMB Seminar Series > Crick Lecture 2023: Innovating metagenomics to explore the strange world of archaeal extrachromosomal elements

Crick Lecture 2023: Innovating metagenomics to explore the strange world of archaeal extrachromosomal elements

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Metagenomic methods have brought to light huge, diverse, linear extrachromosomal elements of Archaea that are referred to as Borgs, given their propensity to assimilate DNA from diverse organisms. Borgs clearly replicate in anaerobic methane-oxidizing archaea yet cannot easily be classified as either viruses or plasmids. We are applying new short read genome curation methods, long-read sequencing information and in silico structural biology tools to comprehensively define their genomes and uncover functions in their enigmatic proteomes. The findings indicate unexpected, highly replicated capacities that alter our perception of these strange, and likely biogeochemically important, entities.

This talk is part of the MRC LMB Seminar Series series.

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