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Transcription and R-loops as a source of genome instability

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A number of eukaryotic factors working at the interface transcription-RNA export plays a role in preventing R-loop formation, one key substrate in the origin of transcription-associated genome instability, which may be triggered by DNA modifying enzymes such as AID . I will present our recent work trying to understand the interconnection between transcription, R-loops and genome instability in yeast and human cells at a genome-wide scale, the impact that replication may have in this interconnection, and how it can result in translocations often associated with cancer.

This talk is part of the MRC LMB Seminar Series series.

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