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LMB Seminar: Identification of alternative pathways for metabolism or cell death using haploid genetics

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Human genes act together in complex networks to perform a myriad of functions. Whereas details maps exist for most biochemical pathways, the wiring of genetic networks in human cells is poorly understood. Using genetics in haploid human cells we have assigned genes to more than a hundred quantitative cellular phenotypes.This approach enables us to identify missing enzymes in cell biology, alternative metabolic routes and a pathway that activates cell death in response to cancer therapeutics.

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