The Cellular Basis for the Cancer-Related Phenomena of Immune Suppression and Cachexia

Add to your list(s) Download to your calendar using vCal

• Doug Fearon
• Thursday 31 March 2011, 16:15-18:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Although cancers elicit immune responses, they occur. This paradox must be understood to improve cancer immunotherapy. “Stromal” cells (all non-cancer cells in the tumor) prevent cancer-specific immune responses from controlling tumor growth, but the diversity of this population has hindered identification of the relevant cell type. We developed a mouse model that enables the conditional ablation of a stromal cell type that was recognized 20 years ago by its expression of the membrane protein, “fibroblast activation protein-alpha”, or FAP . Ablating FAP stromal cells causes immune-mediated necrosis of established tumors. FAP cells reside also in skeletal muscle where their depletion leads to a wasting condition resembling cancer cachexia. Thus, the redistribution of the FAP + cell from normal tissues to tumors may link the cancer-related phenomena of immune suppression and cachexia.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.