New Frontiers in PKA Signaling

Add to your list(s) Download to your calendar using vCal

• Susan Taylor, Professor of Chemistry and Biochemistry and a Professor of Pharmacology at the University of California, San Diego
• Wednesday 09 November 2022, 11:30-12:30
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99725572898?pwd=NG82MzVpQmczczAvdkZzN2lJNkt1UT09.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Over thirty years have passed since that first PKA structure was solved and in so many ways PKA has served as the poster child for the protein kinase superfamily. In addition to trapping each step of catalysis in a crystal lattice and solving isoform-specific holoenzyme structures, by comparing PKA to other kinases we discovered the Regulatory and Catalytic Spines. This hydrophobic core architecture provides us with a conceptual framework to better understand how all protein kinases are activated and regulated as molecular switches. Over the past three years, however, we have also made unanticipated discoveries that open some new frontiers in PKA signaling. C isoforms, for example, are virtually unexplored although they account for ~50% of PKA signaling in neurons. The biomolecular condensates formed by RI that serve as a “Sponge” for compartmentalizing cAMP is another new concept as is our discovery of a PKI -like sequence embedded in the tail of Smoothened, the GPCR that regulates Sonic hedgehog signaling. Our approach to build an interdisciplinary platform where we can move seamlessly from atomic level resolution to cells and tissues allows us to quickly build on new discoveries

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99725572898?pwd=NG82MzVpQmczczAvdkZzN2lJNkt1UT09
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.