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LMB Seminar: Mechanosensing in cancer invasion and metastasis

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Pancreatic cancer is highly metastatic, with a 5-year survival rate of less than 10%. Tumours are hallmarked by accumulation of highly fibrotic extracellular matrix, which correlates with poor prognosis and spread to organs such as liver, lung and peritoneal cavity. Our aim is to understand the molecular connections between force sensing and aggressiveness of tumour cells. We recently discovered a connection between mechanosensing, invasive migration and metabolic supply/demand in pancreatic cancer cells. I will discuss our model for how cells align their cytoskeletal polarity with their metabolic machinery to meet the high demands of the cancer microenvironment. If we can better model and understand this alignment, we can hope to find new ways to target the aggressiveness and spread of pancreatic cancer.

This talk is part of the MRC LMB Seminar Series series.

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