University of Cambridge > > MRC LMB Seminar Series > Structure of TRP channel by single particle cryo-EM

Structure of TRP channel by single particle cryo-EM

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

The Transient Receptor Potential (TRP) ion channel is a large and functionally diverse superfamily, second only to the potassium channels. Members of TRP channel superfamily include the capsaicin receptor, TRPV1 , and the “wasabi” receptor, TRPA1 . TRPV1 is a polymodal signal detector that resides on primary afferent sensory neurons. It is a heat-activated cation channel that is also modulated by various inflammatory agents and contributes to acute and persistent pain. TRPA1 activation is triggered by various pungent agonists such as allyl-isothiocyanate from mustard and allicin from garlic, both generating pungent taste. Enabled by recent technological breakthroughs in single particle cryo-EM, we determined the atomic structures of both TRPV1 and TRPA1 . We also utilized their rich pharmacological information for structural investigation of these two channels in various functional states, aiming to elucidate the mechanism of channel activations.

This talk is part of the MRC LMB Seminar Series series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity