LMB Seminar: Power to the protein: analyse, signal and protect with bacterial superglues

Add to your list(s) Download to your calendar using vCal

• Professor Mark Howarth, University of Cambridge
• Monday 04 December 2023, 11:00-12:00
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/95625236862?pwd=NGttT1d6ay9SWFRqUHMvRWNPdDhyZz09.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

A special feature of the bacterium Streptococcus pyogenes enables spontaneous amide bond formation within its surface proteins. We re-engineered this system to generate an irreversible peptide-protein interaction (SpyTag/SpyCatcher). This reaction is genetically-encodable, specific in diverse biological environments, and occurs at a rate close to the diffusion limit. Latest advances include a toolbox of modules for rapidly controlling protein architectures and interaction switchable by temperature, pH or light. We have also developed another bacterial superglue called NeissLock for covalent reaction to endogenous human proteins via an anhydride. For targeting in the GI tract, we have been engineering plant-based proteins with extreme resilience to low pH and proteases. Applications of the technologies will be discussed for hydrogen-deuterium exchange, cell therapy and vaccination, including for emerging pandemic threats.

X/Twitter account – @HowarthSci

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/95625236862?pwd=NGttT1d6ay9SWFRqUHMvRWNPdDhyZz09
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.