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LMB Seminar: Membrane Mechanics: cryo-EM insights and challenges

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The linear sequence property of genetic information provides critical prior knowledge when interpreting density maps of DNA , RNA, or amino acid chains. It follows that there are persistent gaps in our understanding of biological materials that, like the organization of lipids in a fluid bilayer, lack primary sequence information. I will discuss our efforts to understand the membrane-associated synthesis of chlorophyll, including initial efforts to falsify molecular simulations using halogenated lipid derivatives as contrast agents for cryo-EM imaging.

This talk is part of the MRC LMB Seminar Series series.

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