The Chemical Biology of Large-Scale Transcriptome Analysis

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• Kevin Weeks, University of North Carolina
• Wednesday 06 April 2011, 11:30-13:15
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Our laboratory is blending new RNA chemistries, largely directed at the ribose 2’-hydroxyl group, with quantitative interpretation to create new kinds of chemical microscopes for highly accurate RNA structure analysis. We apply these technologies to important, and otherwise intractable, problems in biology. We have developed a working model for the architecture of an entire HIV -1 genome. This secondary structure model represents, in essence, a diverse set of hypotheses for how RNA structure governs viral replication. Recent functional studies supporting many of these structural hypotheses, plus new work focused on understanding RNA tertiary structure, will be emphasized.

This talk is part of the MRC LMB Seminar Series series.

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