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LMB Seminar Series - Kinetochore Structure

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The protein/DNA complex known as the kinetochore links chromosomes to the microtubules of the mitotic spindle. The kinetochores of budding yeast cells appear to be elementary, unimodular versions of the multimodule kinetochores of metazoan cells. Most of the 50–80 distinct protein species that make up a yeast kinetochore are organized into well-defined subcomplexes. Prof. Harrison has been studying the structures of these subcomplexes using a diverse set of approaches including cryoEM and X-ray crystallography. In this seminar, he will present the latest advances of his group on the structure, function, and evolution of the kinetochore

This talk is part of the MRC LMB Seminar Series series.

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