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LMB Seminar Series- How T cells control secretion to optimise target cell killing

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Killer cells of the immune system recognize and destroy virally infected and cancer cells with remarkable precision. This is controlled by a remarkable polarization within the killer cell once signaling is initiated upon recognition of a target to be killed. The centrosome plays a key role, docking directly at membrane of the synapse formed between killer and target. Our recent work has focused on the molecular changes in the plasma membrane that occur as the synapse forms, and how these control both centrosome docking and secretion, identifying a molecular sensor of T cell signaling that directly controls phosphoinositide specialization.

This talk is part of the MRC LMB Seminar Series series.

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