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Remodeling of the erythroid proteome

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Global remodeling of the proteome is an essential though little-understood aspect of terminal differentiation, consisting of the programmed elimination of most generic constituents of the cell in parallel with abundant synthesis of a small number of new, cell-type-specific proteins such as globin. Reticulocytes are a canonical example of a proteome in a massive and rapid transition. However, the mechanisms that drive rapid turnover of normally stable proteins in the erythroid lineage remain largely unknown. We will describe work implicating Ube2O in this process­–a ubiquitin-conjugating enzyme that is highly and selectively upregulated in the erythroid lineage. Our findings indicate that successful terminal differentiation can be driven by late-stage induction of a specific ubiquitination program that is specific yet broad on scope.

This talk is part of the MRC LMB Seminar Series series.

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