CANCELLED - LMB Seminar: RNA Meets DNA: Dangerous Liaisons in the Genome

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• Karlene Cimprich - Stanford University School of Medicine, Department of Biochemistry
• Thursday 03 October 2024, 10:30-11:30
• CANCELLED.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

R-loops are three-stranded nucleic acid structures that form co-transcriptionally and which are comprised of an RNA -DNA hybrid and a displaced strand of ssDNA. Although R-loops have important functions in cells, their dysregulation can also lead to genome instability. We recently showed that a surprising consequence of dysregulated R-loop metabolism is the release of RNA -DNA hybrid fragments into the cell and subsequent sensing of these hybrids by innate immune receptors. In this seminar I will describe our recent studies demonstrating how these pathological R-loops arise and features that cause them to threaten genome stability.

This talk is part of the MRC LMB Seminar Series series.

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