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If you have a question about this list, please contact: Sina Beier. If you have a question about a specific talk, click on that talk to find its organiser. 15 upcoming talks and 312 talks in the archive. Programmed DNA elimination in insectsHost – John Welch
How the double helix was really discovered, and what Rosalind Franklin thought about itHost – Frank Jiggins
Bacterial evolution in the lungHost – Kate Baker
Cambridge RNA Club - IN PERSON
What can butterfly hybrid zones tell us about the genomic architecture of species barriers?Host – Richard Durbin
Cambridge RNA Club - July session ON ZOOM
Cambridge RNA Club - June session IN PERSON
Cambridge RNA Club - May session IN PERSON
RNA Collaborative Seminar Series special event
Competition for phospholipids drives astrocyte morphogenesis in the CNSHost - Cahir O'Kane
Mutate everything: mapping the energetic and allosteric landscapes of proteins at scaleHost – Richard Durbin
Vector Genomics and the Malaria Cell AtlasHost - Frank Jiggins
Cambridge RNA Club - April session ON ZOOM
E. coli and the Game of ClonesHost – Kate Baker
Cambridge RNA Club - March session IN PERSON
Pathogens through space and time - Lessons from high-throughput screening for ancient pathogen DNAHost - Charlotte Houldcroft
Building patterning-dependent chromatin states during development.Host - Erik Clark
When the non-coding codes: Mining the microproteome for novel regulators of cancer cell plasticityHost - Steve Russell
Epigenetic InheritanceHost - Ritwick Sawarkar
The Mechanics of Cancer Cell DivisionHost - Ben Steventon
Beyond chromatin: Histones as developmental regulators in DrosophilaHost - Felipe Karam Teixeira
An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineagesHost - Zach Baker
Multiscale synthesis of coupled dynamic gene expression during neural developmentHost - Ben Steventon
The evolution of organs and cell types.Host - Francesco Nicola Carelli
Tracking pathogens in space and time: something old, something newHost - Charlotte Houldcroft
Using synthetic biology to understand pattern-forming gene regulatory networks and their evolutionHost - Erik Clark
Challenges and solutions in identifying the genes responsible for local adaptationHost - John Welch
Novelty and developmental systems drift in embryos of fliesHost - Erik Clark
Population structure and effects of consanguinity on complex disease in British South AsiansHost - Richard Durbin
Pathogen phylodynamics: from historical epidemics to contemporary outbreaksHost - Henrik Salje
Whodunnit in the genome: Fingerprints of mutagenesis reveal culprits of cancerHost - Cahir O'Kane
Early Life Microbiomes and Long-Term HealthHost - Charlotte Houldcroft
Regulation of gene expression during the awakening of the zygotic genomeHost - Erik Clark
Mechanism of neural differentiationHost – Lara Busby
Mitochondrial vesicles in immunology and evolutionHost - Hansong Ma
Genetic studies of epigenetic clocks in different speciesHost - Richard Durbin
Connecting Sensory Perception to Longevity in C. elegansHost – Ritwick Sawarkar
Patterns of purifying selection and adaptive evolution in SARS-CoV-2Host – Henrik Salje
Single Cell Technologies : A Bioinformatician’s perspectiveHost – Bianca De Sanctis
Chromosome Architecture: Lifting the Lid on Loop ExtrusionHost - Marco Geymonat
Epigenetics and genome dynamics: what can we learn from ciliates?Host - Felipe Karam Teixeira
Base Editing and Prime Editing: Precise Gene Correction Without Double-Strand DNA BreaksHost - Lin Wang
Why is Wolbachia-induced cytoplasmic incompatibility so common?Host - Frank Jiggins
A system-wide quantitative map of RNA subcellular re-localization in response to UPR activation
Regulation of physiology via a dietary lipid metabolite.Host - Felipe Karam Teixeira
Using human genetics to define a spectrum of axon vulnerabilityHost - Cahir O’Kane
How does complexity arise from molecular interaction?Host - Ben Steventon
Wolbachia, African-River Blindness and Big SurHost: Frank Jiggins
Unlocking lncRNA functions using an arrayed CRISPRi screening platform with cellular and molecular phenotyping
Hacking the germline : how paralogs bend the rules of gene expression
A guiding torch at the poles: key roles of the centrosome during asymmetric cell divisionHost - Marco Geymonat
The evolution of polychromatic ‘greenbeard’ genesHost - Carol Edwards
Transposons and evolutionary novelties of a symbiotic genome
RNA Length has a non-trivial effect in the stability of biomoelecular condensates formed by RNA-binding proteins
RNA Collaborative Seminar Series special event
Robust tuning of epigenetic memory by resource competition
LINE1 biology and its interactome dynamics after drug treatment
Mechanics of blastocyst morphogenesisHost - Chaitanya Dingare
Exploring host-tumour metabolic interactions using DrosophilaHost - Chaitanya Dingare
Asymmetric cell division and germline immortalityHosts - Hansong Ma and Ason Chiang
Transparency, reproducibility, and adaptability in data analysis.Host: Elves Duarte
Investigating the evolution and development of body plans and body parts in arthropodsHost - Steve Russell
Mending broken hearts with neural crest cellsHost: Ben Steventon
Inspecting the early secretory pathway with whole-cell, volumetric FIB-SEM in fed and starved cellsHost: Cahir O'Kane
Bacterial condensates under stressHost: Rosana Collepardo
Coping with Mechanical Stress: Tissue dynamics in development and repairHost: Hansong Ma
Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism.Host: John Welch
Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology & StructureHost – Richard Durbin
The origin of mitochondrial DNA mutations: population genetics and diseaseHost: Cahir O'Kane
Genome regulation by ATP-dependent chromatin remodeling and phase-separationHost: Rosana Collepardo-Guevara
Human Immunity – one cell at a timeHost: Anne Ferguson-Smith
PP2A-B55 inhibitors Arpp19 and ENSA define the cell cycle program by controlling the temporal pattern of protein phosphorylationHosts: Helene Rangone-Briatte and David Glover
This talk has been cancelled and will be rescheduled for later this year.Host: Hansong Ma
Molecular and evolutionary processes generating variation in gene expressionHost: Frank Jiggins
Defining intrinsic determinants of regeneration ability and inability.Host: Ben Steventon
Genomic Scope of Adaptive Mutations in the Face of Environmental ChallengesHost: John Welch
Cone subtype specification in human retinal organoidsHost: Hansong Ma
Targeting viral RNA for degradation : the ZAP antiviral system
Deciphering the RNA interactome of SARS-CoV-2
From genomes to genealogies: mapping the history of humans and their genetic variation using ancient and modern genomesHost: Aylwyn Scally
RNA uridyl transferases TUT4/7-mediated control on tumour fitness
Control of global translation by endogenous RNA G-quadruplex structures
The role of aneuploidy in tumorigenesis.Host: Marco Geymonat
Shaping tissues: the role of mechanics across different scales.Host: Ben Steventon
Chromosomal evolution in Nematodes, and other adventures on the Tree of LifeHost: Richard Durbin
[Cancelled] P body phase transitions govern RNA regulation during early Drosophila development
[Cancelled] Replenishing the ends : Structural Mechanism of Human Telomerase
Mixing mitosis and meiosis in DrosophilaHost: Helene Rangone-Briatte
Bullseye! Understanding the mechanisms of petal patterningHost: Ben Steventon
Targeting cancer stem cells while enhancing healthy tissue functions - a novel paradigm for cancer therapies
A bioinformatic strategy for allele-specific RNA expression for distant tomato crosses
This talk has been cancelled
Genomics of speciation and adaptation in the Lake Malawi cichlid fish radiationHost: Aylwyn Scally
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics.Host: Michael Imbeault
The genome landscape: consequences of repetitive DNA organization and evolution in diploid and polyploid cropsHost: Anne Ferguson-Smith
R-loop coupled chromatin silencing at Arabidopsis FLC
How epithelial cells polarise and why this goes wrong in cancerHost: Hansong Ma
A small RNA-based innate immune system guards the integrity of germ cell genomesHost: Anne Ferguson-Smith
Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
Structural studies of ribosome-associated quality and quantity control
The Flux Capacitor: How mitochondria shape the evolution of complexityHost: Richard Durbin
Condensation propensity of TDP-43 specifies the bound and regulated RNAs
Identifying and characterising RNA viruses in publicly available high throughput sequencing data
Minimal and Ancestral GenomesHost: Richard Durbin
Centrosome amplification and cancer: reaching outHosts: David Glover & Paula Coelho
What drives the dependence of human germline mutation rates on sex, age, and time?Host: Richard Durbin
Transposable elements and the evolution of the human brainHost: Michael Imbeault
A new force awakens: comparative approach to tissue morphogenesis in insectsHost: Berta Verd
Think Global Act Local: do local morphological changes influence differentiation of pluripotent cells?Host: Ben Steventon
Role of the endosomal network in cell and tissue organizationHost: Alfonso Martinez-Arias
Deciphering the structure-function relationships of lncRNAs
Integrating protein, RNA and RBP localisation maps
Super-resolution imaging - STED and related advanced microscopy techniquesHosts: Ben Steventon and Ian Clark
Epigenetic inheritance in mammalsHost: Sam Lewis
Experimental evolution in cancer cell linesHost: Jane Charlesworth
How like begets like: lessons from RNA silencing in C.elegans
Queuosine-modified tRNAs confer nutritional control of protein translation
Unearthing structure and complexity in human and great ape evolutionHost: Chris Illingworth
The Structure of Poly(A) Determines Deadenylation Specificity
Single cell full length cDNA library protocol with error correction
Cell cycle controls enforcing asymmetric spindle pole fate in budding yeastHost: Helene Rangone-Briatte
Ancient genomic history and adaptation of human populations in AfricaHost: Aylwyn Scally
Organoids and clonal analysis to study cell community interactions during pancreas developmentHost: Alfonso Martinez-Arias
SmRNA cap methylation and its role in transcription
Killing two viruses with one transposon: The doc transposable element mediates anti-viral function of genes
Hacking the gene expression machinery for genome defenseHost: Felipe Karam Teixeira
The Genetic Basis of Clinal AdaptationHost: Frank Jiggins
How to make or break an axon: the roles and regulation of neuronal microtubulesHost: Cahir O’Kane
RNA modification detection and functional analysis by mass spectrometry and deep sequencing
SLAMseq: Thiol-linked alkylation for the metabolic sequencing of RNA
How evolution of mt-rRNA drives transformation of mitoribosomes
The structural plasticity of the Zika virus genome in human cells
Centriole Duplication: from body coordination in flies to skin cell biology and cancerHost: Alexis Braun
Regulatory RNAHost: Martyna Popis
Versatility and dynamics of transcriptional responses to NotchHost: Anne Ferguson-Smith
Characterisation of primary RNA methylations and their role in cancer
Deciphering new aspects of G-quadruplex mediated post-transcriptional control
Spatially resolved transcriptomics to probe 3D RNA organization
Control of gene expression and cell cycle progression by mRNA nuclear sequestration
Cerebral organoids: modelling human brain development and tumorigenesis in stem cell derived 3D cultureHost: Michaela Frye
Combining tools and technologies to identify post-transcriptional modifications in RNA
Eukaryotic cell division and its originsHost: Alexis Braun
Viral evolution on sub-phylogenetic timescales
Scaling of tissue proportions to body size during vertebrate developmentHost: Alfonso Martinez Arias
Environmental stress, cryptic variation and innovation in the simplest molecular systemsHost: Frank Jiggins
Quantitative HCR for RNA FISHing- Have you heard of it yet
Cryo-EM shows mechanism of 3' splice site selection
DNA methyltransferase(s), transposons and spermatogenesisHost: Eric Miska
Conscious coupling: DEPS-1 links PIWI to endo-siRNA production in C. elegans
Rfam 13.0: The genome-centric sequence database
The Translational Response to Amino Acid Starvation in S. Pombe
Functional dissection of 3'UTR and RNA cis-regulatory elements by CRISPR-Cas9 genome engineering
An Editor’s Guide to Effective Science CommunicationHost: Sudhakaran Prabakaran
Capturing human axial progenitors in vitroHosts: Alfonso Martinez-Arias & Shlomit Edri
The evolution of meiosis and meiotic recombination in Arabidopsis arenosa.Host: Aylwyn Scally
Formation and disease relevance of axonal endoplasmic reticulum, a "neuron within a neuron”.
Visualize gene expression and genetic variants in the central and peripheral nervous systems with the RNAscope technology
piRNA-mediated regulation of transposon alternative splicing in soma and germline
Cheating in Pseudomnas aeruginosa drives switch to privatisation of an essential functionHost: Chris Illingworth
MicroRNAs and other regulatory RNAs
Title to be confirmed
Coordination of spindle positioning and cell cycle progression in yeastHost: Marco Geymonat
Feedback cross-regulation between TDP-43 and paraspeckles promotes efficient exit from plutipotency
Common genetic variation drives molecular heterogeneity in human iPSCs
The genetic analysis of population-scale dataHost: Aylwyn Scally
Post-transcriptional mechanisms that time development
Major glial changes in the human aging brain: from RNA to cells
Understanding the causes of variation in nucleotide diversity across the genomeHost: Aylwyn Scally
Rate and pattern of evolutionary change in the gut microbiota as revealed by a commensal bacteriaHost: Chris Illingworth
Evidence for miRNA-mediated transcriptome regulation in the parasitic flatworm Schistosoma mansoni
Sperm Mediated Transgenerational Inheritance
Decoding transcriptional regulation.Host: Alexis Braun
Non-coding solutions to developmental challengesHost: Anne Ferguson-Smith
Comparative population genomics in animals: genetic diversity, adaptive rate, species barrierHost: John Welch
Predicting the pleiotropic effects of circadian timing, from clock gene expression to biomass.Host: Alfonso Martinez-Arias
The evolution of arthropod small RNA pathways
Evaluation of Lexogen Quantseq for gene expression profiling of novel compounds in drug discovery
Stem cell control in the Drosophila gutHost: Alexis Braun
Targeted polyA tail removal by the Ccr4-Not complex
NGS techniques for challenging RNA sample types
Defining transcription units across the human genome.Host: Michaela Frye
Using experimental evolution to understand adaptation from standing genetic variation.Host: Frank Jiggins
Structure of the catalytic spliceosome
A transmissible RNA pathway in honey bees
Directing and shaping the inside-out axis of the vertebrate brainHost: Ben Steventon
Towards a complete view of the genetics of gene expression variation in yeastHost: Chris Illingworth
Neural mechanisms of behavioral switchesHost: Liria Masuda-Nakagawa
Ptbp1 post-transcriptional action is essential for the formation of germinal centre B cells and the generation of high affinity antibodies.
Parallel reverse genetic screening in mutant human cells using transcriptomics.
New SHAPEs of retroviral RNAs
SMall RNAs control transposons during demethylation in mouse ES cells.
‘Uncovering new “lnc's” in mitosis : an RNA perspective.’
‘Cell types in the mouse brain as revealed by single-cell RNA-seq.’
Beyond the reference genome: inference using prior knowledge of the diversity of a species.Host: Chris Illingworth
Genome diversity and evolution of DNA methylation genome in the human genome.Host: Aylwyn Scally
Modified RNA and grammer education for the naive immune system
Role of long noncoding RNAs in hematopoiesis
Gene and Genome Regulation in Early Fruit Fly Neurogenesis.Host: Steve Russell
Selective control of genome maintenance pathways by RNA processing factors
Introduction to RNAcentral, a non-coding RNA sequence database
Role of neuromesodermal progenitors in axial elongation.Host: Alfonso Martinez-Arias
Checkpoint and non-checkpoint functions of Drosophila Mad1 and RZZ.Host: Yuu Kimata
Structural and functional studies of the machinery of riboregulation in E. coli.
CryoEM structure of the spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution.
Single cell RNA-sequencing reveals a continuous spectrum of differentiation in haematopoietic cells.Host: Anne Ferguson-Smith
An experimental assay of the genotype to phenotype connection.Host: John Welch
CrPV-IRES: the dynamic tale of a molecular pirate
Using LNA enhanced oligonucleotides for elucidating microRNA and RNA functions
Genomics approaches for the investigation of gene regulation.Host: Steve Russell
Breaking the silence: defense and counter-defense in antiviral RNA silencing pathways of insects.Host: Frank Jiggins
Transcriptional regulation and downstream program of Hox and Cdx genes during axial development in the mouse embryo.Host: Alfonso Martinez-Arias
Targeting Polycomb repression to the genome.Host: Steve Russell
MiRNA-containing gene regulatory networks in development
SIRVs – External Spike-in Transcript Variant Controls for RNA-Seq
Intra-tumour heterogeneity and genomic rearrangements in solid cancers.Host: Aylwyn Scally
Into the void: bridging the gap between risk genes and psychiatric phenotypes.Host: Cahir O' Kane
Mechanism and Regulation of miRNA-mediated Repression in Mammalian Cells including Retinal Photoreceptors
Novel insights into substrate recognition and targeting of mRNA to nonsense-mediated decay
LNA GapmeRs represent a powerful alternative for knocking down mRNAs and lncRNAs.
Codon usage determines mRNA levels in Trypanosoma brucei.
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo.Hosts: Steve Russell and Boris Adryan
Model systems to study embryonic patterning.Host: Alfonso Martinez-Arias
New dimensions of antiviral immunity in insects.Host: Frank Jiggins
Biogenesis and function of circular RNAs (circRNAs).Host: Boris Adryan
Single-cell dynamics of the proliferation-quiescence decision.Host: Viji Draviam
How do miRNAs work?
Small RNAs mediate trans-generational epigenetic inheritance in C. elegans
Post-transcriptional RNA processing in the remnant chloroplast of the malaria parasite Plasmodium
tRNA that masquerades under rRNA to promote translation of mRNA in mitochondria.
Rapid microbial evolution: From the lab to the clinic and back again.Host: Frank Jiggins
"HSV-1 causes widespread host-specific disruption of transcription termination"
“The Nuclear Matrix Protein Matrin3 Regulates Splicing and Forms Overlapping Networks with PTB”
Causes and Consequences of New Mutations.Host: Cahir O'Kane
How dynein and its co-factors at the kinetochore ensure chromosome segregation fidelity.Host: Viji Draviam
Beyond cancer genetics: dissecting the transcriptional and epigenetic regulation in leukaemia.Host: Boris Adryan
Single cell transcriptomics.Host: Anne Ferguson-Smith
Mitotic kinases and phosphatases work together to shape the right response.Host: Yuu Kimata
Chemical and proteomic analysis of spliceosomes and multi protein complexes
Annotation and identification of potentially functional lncRNAs
Imaging gene activity in living cells.Host: Viji Draviam
Asymmetry in Drosophila neuroblasts: centrosomes & mRNA.Host: Yuu Kimata
Using zebrafish models to identify novel alleles affecting human behaviour- a proof of principle study using smoking as an example.Host: Boris Adryan
Decipher the RNA structural code: A transformative platform reveals novel regulatory features.
Investigating the consequences of age-linked gene expression changes
COMT: from single nucleotide polymorphism to whole brain function.Host: Boris Adyran
Large scale genomic analyses of complex traits in human populations.Host: Anne Ferguson-Smith
The memory of retinal stem cells?Host: Alfonso Martinez-Arias
Regulation of Notch signalling by the endosomal pathway.Host: Alfonso Martinez-Arias
Targeted Sequencing Reveals The Genome’s Fine Details
Structure of Prp8 and its implications for the spliceosomal active site
Understanding mechanisms of long-range gene regulation.Host: Boris Adyran
Organisation and Regulation of DNA supercoiling domains in Mammalian Chromatin.Host: Boris Adryan
C. elegans development: getting the seams right and living a balanced life.Host: Melissa Antoniou-Kourounioti
The impact of viral IκB-like ANK proteins on host-parasitoid interactions.Host: Boris Adryan
‘Computational analysis of small RNA function in animals.’
Regulation of microRNA expression during virus infection.
(At least) 3 ways to publish a pigeon genome.Host: Frank Jiggins
Shaping and reshaping regulatory loops in Drosophila morphogen signaling.Host: Boris Adryan
Molecular mechanisms of Mediator complex recruitment by transcription factors.Hosts: Boris Adryan and Alfonso Martinez-Arias
From stripes to blood flow: cell fates of the lateral plate.Host: Boris Adryan
"The end of the message: Insights into mRNA deadenylation"
Directional, amplification-free RNA-seq in for AT-rich malaria parasites
Computational insights into stem cell differentiation using dynamic hybrid modelling.Host: Steve Russell
Origin and evolution of novel microRNAs.Host: Boris Adryan
'Towards the RNA structure of everything'
'Small RNA biogenesis in the germline of C. elegans'
Targets of T cell responses against malaria liver infection: immunology meets experimental genetics.Host: Boris Adryan
A Drosophila resource to study human pathology.Host: Sarah Bray, PDN (sjb32@cam.ac.uk)
Engineering flies.Host: Cahir O'Kane (c.okane@gen.cam.ac.uk)
Molecular insights into the ecology, epidemiology and evolution of bat rabies.Hosts: John Welch and Ben Longdon
Studying the invasive migration of Drosophila immune cells.Host: Boris Adryan
Vaccinia virus has evolved the Bcl-2 family of proteins to thwart the host innate immune system.Host: Boris Adryan
"Structure-function analysis of non-coding human Y RNA"
Checks and Balances in Drosophila Muscle and Heart Differentiation Programs.Host: Alfonso Martinez-Arias
Deconstructing Greatwall Kinase.Host: Viji Draviam
Epigenetic contribution to transgenerational inheritance.Host: Ian Furner
Structural insights into the molecular mechanisms of accurate chromosome segregation.Host: Viji Draviam
Immune-metabolic interaction in Drosophila.Host: Boris Adryan
Widespread translation of small Open Reading Frames from coding regions, UTRs and non-coding RNAs.Host: Alfonso Martinez-Arias
Motors, rulers and clocks in chromosome segregation.Host: Viji Draviam
The evolution of the RNAi pathway and RNA viruses in Drosophila
The dynamics of Dengue virus transmission in nature
How does the kinetochore orchestrate a functional checkpoint signal?Host: Viji Draviam
Feedback control of the anaphase-telophase transition.Host: Viji Draviam
Sibling Rivalry and Stress Tolerance: the Single-Cell Biology of Mycobacteria.Host: Viji Draviam
Epigenetic regulation of tissue growth in Drosophila.Host: Boris Adryan
The evolutionary dynamics of unusual reproductive systems.Hosts: Eli Vieira Araujo Jnr and John Welch
Tracking transmission and evolution of bacterial pathogens with high-throughput genomics.Host: Frank Jiggins
Sequence-based discovery of transcriptional targets.Host: Boris Adryan
Tips at the Edge: Regulation of Microtubule Dynamics at the Cell Cortex.
Molecular mechanisms that mediate the adaptation to hypoxia in Drosophila.
Linking the mitotic spindle to the plasma membrane during cytokinesis.
How to maintain a stable genome: A Passenger Perspective.
Regulation of Muscle Stem Cell Fate
Cell specification in the mouse blastocyst inner cell mass: interplay between Nanog, Gata6 and the Fgf signalling pathway.
The mitotic checkpoint - a structural perspective.
Quantification and modeling of spindle positioning and size regulation in the C. elegans embryo
Hox Control of a Drosophila Feeding Circuit.
Perspectives on Next Generation DNA Sequencing.
Mechanisms of Transcriptional Repression during Development.
Systems-based, quantitative analyses of genomic function and variation.
Gene expression divergence recapitulates the developmental hourglass model.
PTEN phosphatase-independent maintenance of apical membrane integrity during colorectal glandular morphogenesis.
A life in science: from academia to industry and back.
Phase-shifted gene-activity oscillations during embryo development - a real-time imaging approach.
Kick Off Meeting of the Cambridge RNA Clubno tie required, food and drink provided
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Dr Laura Ross from Institute of Evolutionary Biology, The University of Edinburgh .
Thursday 14 November 2024, 13:00-14:00