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Early Life Microbiomes and Long-Term Health

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If you have a question about this talk, please contact Caroline Newnham.

Host - Charlotte Houldcroft

Humans are born without microbiota but are rapidly colonised by microbes from our mothers and the surrounding environment at birth. The dynamic processes of gut microbiota colonisation and assembly are poorly understood, but possibly represent a deeply evolved ecological succession analogous to an infant’s organ and system developmental programmes. Importantly, clinical procedures (C-section, antibiotics) that perturb microbiota acquisition and assembly are associated with a higher rate of infection, autoimmunity, metabolic syndromes in early childhood. Therefore, the stereotypic assembly trajectory of the microbiota is believed to drive children’s immune development and growth. This seminar will discuss the UK Baby Biome Study aimed to map microbiota assembly in infants to identify associations between the stages of microbiota assembly and landmarks in a child’s growth and development, and to inform the discovery of microbiota-focused interventions to optimise a child’s growth, development and disease resistance.

This talk is part of the Genetics Seminar series.

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