Tips at the Edge: Regulation of Microtubule Dynamics at the Cell Cortex.

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• Professor Dr Anna Akhmanova from Cell Biology, Faculty of Science, Utrech University
• Thursday 14 March 2013, 14:30-15:30
• Biffen Lecture Theatre.

If you have a question about this talk, please contact Caroline Newnham.

Microtubule plus end tracking proteins (+TIPs) are a group of factors, which specifically associate with the growing microtubule ends and regulate their dynamics and interactions with various cellular structures. Recent studies showed that a sequence motif Ser-any amino acid-Ile -Pro (SxIP) embedded in a basic, serine and proline rich region can target a variety of proteins to microtubule ends by interacting with the members of End Binding (EB) family. Since this motif is relatively short, it can arise easily during evolution, and it is thus possible that multiple yet undiscovered EB-dependent +TIPs are encoded in mammalian genomes. In my talk, I will describe the results of our searches for EB-binding +TIPs by combining proteomics and bioinformatics approaches, and the known +TIP functions. I will focus on our recent data on the mechanisms of regulation of microtubule dynamics at the cell cortex.

This talk is part of the Genetics Seminar series.

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