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Deciphering the structure-function relationships of lncRNAs

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If you have a question about this talk, please contact Giulia Furlan.

It is now clear that the majority of the genome is differentially and dynamically transcribed to produce not only mRNAs but also tens if not hundreds of thousands of short and long non-protein-coding RNAs that show specific expression patterns and subcellular locations, with many shown to play important etiological roles in development, brain function, cancer and other diseases. These noncoding RNAs function at many different levels of gene expression and cell biology, including translational control, subcellular domain formation, and guidance of the epigenetic processes that underpin development, brain function and physiological adaptation. I will present recent data that indicates that exons in long noncoding RNAs are near-universally spliced, suggesting that the exon is the modular unit of function, which is supported by analysis of evolutionarily conserved RNA structures, and which provides a rational framework for determining their domains and interactions.

This talk is part of the Cambridge RNA Club series.

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