Defining transcription units across the human genome.

Add to your list(s) Download to your calendar using vCal

• Professor Nick Proudfoot, Sir William Dunn School of Pathology, University of Oxford
• Thursday 03 November 2016, 14:00-15:00
• Biffen Lecture Theatre, Department of Genetics, Downing Site.

If you have a question about this talk, please contact Caroline Newnham.

Host: Michaela Frye

The dramatic achievement of sequencing the whole human genome has been tempered by the subsequent realisation that the human transcriptome is far more complex than initially anticipated; far from any clear understanding of how and why it is made. My lab has focused on the basic mechanism of transcriptional termination and associated RNA 3 ’ end processing by the major RNA polymerase II (Pol II) that is responsible for the synthesis of all pre messenger RNA and most non coding RNAs. We have uncovered a surprising diversity of termination mechanisms using gene specific analyses. We are now applying new native elongating transcription (NET) sequencing strategies to define all Pol II transcription units (especially mammalian NET -seq). Using this technology we are uncovering unanticipated mechanistic cross talk between the basic transcription process and associated pre-mRNA and long non coding RNA processing.

This talk is part of the Genetics Seminar series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biffen Lecture Theatre, Department of Genetics, Downing Site
• Bioinformatics and other interests
• Biology
• Centre for Health Leadership and Enterprise
• DevBio
• Genetics Seminar
• Genetics Seminar Series
• Graduate-Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• PMRFPS's
• ji247's list
• my_list
• ndk22's list
• other talks

Note that ex-directory lists are not shown.