An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineages

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• Professor Daniel Falush from Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences
• Wednesday 06 December 2023, 14:00-15:00
• Biffen Lecture theatre and Zoom.

If you have a question about this talk, please contact Caroline Newnham.

Host - Zach Baker

The colonization of our stomachs by Helicobacter pylori is believed to predate the oldest splits between extant human populations. We identify a “Hardy” ecospecies of H. pylori associated with indigenous groups, isolated from people in Siberia, Canada, and USA . The ecospecies shares the ancestry of “Ubiquitous” H. pylori from the same geographical region in most of the genome but has nearly fixed SNP differences in 100 genes, many of which encode outer membrane proteins and previously identified host interaction factors. For these parts of the genome, the ecospecies has a separate, independently evolving gene pool with a distinct evolutionary history. H. acinonychis, found in big cats, and a newly identified primate-associated lineage both belong to the Hardy ecospecies and both represent human to animal host jumps. Most strains from the ecospecies encode an additional iron-dependent urease that is shared by Helicobacter from carnivorous hosts, as well as a tandem duplication of vacA, encoding the vacuolating toxin. We conclude that H. pylori split into two highly distinct ecospecies approximately 300,000 years ago and that both dispersed around the globe with humans. Coexistence has likely been possible because the ecospecies are adapted to different host diets, but the Hardy ecospecies has gone extinct in most parts of the world. Our analysis also pushes back the likely length of the association between H. pylori and humans.

This talk is part of the Genetics Seminar series.

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