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Asymmetric cell division and germline immortality

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  • UserProfessor Yukiko Yamashita, Whitehead Institute for Biomedical Research, Cambridge, MA
  • ClockThursday 24 February 2022, 14:00-15:00
  • HouseZoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Hosts - Hansong Ma and Ason Chiang

Germline is the only lineage that is capable of passing genetic information to the next generation. It remains poorly understood how the genome of the germ cells can be passed from generation to the next through evolutionary time scale. ribosomal DNA (rDNA), which encodes catalytic subunits of ribosome, exists as 100s of tandem repeats to meet the demand of ribosome biogenesis. This repetitiveness causes copy number loss during aging. Here I describe the mechanism by which rDNA copy number is maintained in germline to confer ‘immortality’.

This talk is part of the Genetics Seminar series.

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