Genomics approaches for the investigation of gene regulation.

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• Dr Jim Hughes, Hughes Genome Biology Group, Oxford
• Thursday 19 November 2015, 14:00-15:00
• Biffen Lecture Theatre, Department of Genetics, Downing Site.

If you have a question about this talk, please contact Caroline Newnham.

Host: Steve Russell

“A main research interest of the group is to study the processes that determine whether RNA is or is not produced from a genomic locus as cells develop into red blood cells (erythropoiesis) and which factors determine the rate at which it is produced. We employ most of the current genome-wide methods to determine which parts of the genome are being transcribed into RNA and to correlate this activity (transcription) with molecular changes at the linked regulatory elements and in the 3D structure of the local environments. Although we use many existing methodologies the group also develops novel assays where needed to fill many of the current deficiencies in our ability to assess genome behaviour. One of the most difficult problems when trying to understand gene regulation on the scale of genome or at individual genes is to determine which regions of the genome control the expression patterns and levels of any particular gene. To address this problem we developed the Capture-C 3C technologies, which in combination with our combined genomics data, allows us to link genes and regulatory elements en masse in the erythroid system.”

This talk is part of the Genetics Seminar series.

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