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Phase-shifted gene-activity oscillations during embryo development - a real-time imaging approach.

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If you have a question about this talk, please contact Caroline Newnham.

In our group, we are focusing on the temporal aspect of embryonic development and thus on the role of embryonic clocks, or oscillators. Oscillations in Wnt, Fgf and Notch-signaling pathway activity (period ~2hours) have been identified during mesoderm patterning in vertebrate embryos and are linked to the formation of pre-vertebrae, or somites. Most strikingly, oscillations occur phase-shifted between neighbouring cells, producing spatio-temporal activity patterns within the embryo. Using a combination of genetically engineered dynamic reporter mouse lines, functional perturbations and quantitative in vivo measurements, we currently address the principles underlying synchronization.

This talk is part of the Genetics Seminar series.

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