Mitotic kinases and phosphatases work together to shape the right response.

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• Dr. Adrian Saurin, Division of Cancer Research, Medical Research Institute, University of Dundee
• Thursday 05 February 2015, 14:30-15:30
• Part II Room, Department of Genetics.

If you have a question about this talk, please contact Caroline Newnham.

Host: Yuu Kimata

We have recently identified a feedback network between two phosphatases (PP1 and PP2A -B56) and two kinases (Aurora B and Mps1) that ensures a rapidly switchable spindle checkpoint response at kinetochores. I will present this data and use it as a paradigm to highlight why investigating kinase-phosphatase coupling is important if we are to properly understand signal responses. Although kinases and phosphatases are antagonistic forces that turn signals on or off, they also work together in many different contexts to shape the right type of response. I will highlight some examples of this and present a system we have established to investigate this further, which allows the dynamic control of endogenous phosphatase complexes within defined subcellular compartments in mammalian cells.

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