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Feedback control of the anaphase-telophase transition.

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If you have a question about this talk, please contact Caroline Newnham.

Host: Viji Draviam

Faithful chromosome segregation during anaphase of mitosis requires the physical and synchronous separation of two sets of sister-chromatids that will give rise to genetically identical daughter cell nuclei. Critically, nuclear envelope reassembly at telophase must therefore enclosure each and entire set of sister-chromatids, implying spatiotemporal coordination with the mechanisms that govern anaphase. Using Drosophila melanogaster S2 cells has model system, we identified a novel feedback control mechanism that delays chromosome decondensation and nuclear envelope reformation is response to slow spindle elongation during anaphase. We show that this mechanism is dependent on a gradient of Aurora B activity at the spindle midzone. In this presentation I will present evidence in support of a new mitotic checkpoint that prevents premature chromosome decondensation and nuclear envelope reassembly before effective separation of sister chromatids is achieved.

This talk is part of the Genetics Seminar series.

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