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Coordination of spindle positioning and cell cycle progression in yeast
If you have a question about this talk, please contact Caroline Newnham.
Host: Marco Geymonat
The positioning of the mitotic spindle along the mother-daughter cell polarity axis is critical for the outcome of cell division in asymmetrically dividing budding yeast cells. A surveillance mechanism, known as the spindle position checkpoint (SPOC), senses defects in spindle orientation thereby inhibiting mitotic exit and cytokinesis. I will discuss our currently understanding of SPOC activation and how temporal and compartment-specific regulatory networks determine mitotic exit in this system.
This talk is part of the Genetics Seminar series.
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