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Coordination of spindle positioning and cell cycle progression in yeast

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If you have a question about this talk, please contact Caroline Newnham.

Host: Marco Geymonat

The positioning of the mitotic spindle along the mother-daughter cell polarity axis is critical for the outcome of cell division in asymmetrically dividing budding yeast cells. A surveillance mechanism, known as the spindle position checkpoint (SPOC), senses defects in spindle orientation thereby inhibiting mitotic exit and cytokinesis. I will discuss our currently understanding of SPOC activation and how temporal and compartment-specific regulatory networks determine mitotic exit in this system.

This talk is part of the Genetics Seminar series.

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