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Molecular mechanisms that mediate the adaptation to hypoxia in Drosophila.

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If you have a question about this talk, please contact Caroline Newnham.

Adaptation to hypoxia involves a coordinated regulation of a wide range of genes involved in restoring oxygen homeostasis. This response is mainly directed by the hypoxia-inducible factor (HIF) family of transcription factors, which are heterodimeric proteins consisting of two subunits: a HIF -α subunit that is tightly regulated by oxygen and a constitutive HIF -β subunit. Oxygen negatively regulates HIF -α through proteasomal degradation, blockage of transcriptional co-activator recruitment and subcellular localization. This hypoxia-responsive system is conserved in Drosophila melanogaster, being Sima and Tango the orthologues of HIF -α and HIF -β respectively. We have performed a genome-wide RNAi screen, aimed to the identification of genes required for Sima activity in hypoxic conditions. We have found more than 20 novel regulators that are required for this response in vivo and characterized some of their mechanism of action.

This talk is part of the Genetics Seminar series.

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