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DNA methyltransferase(s), transposons and spermatogenesis

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If you have a question about this talk, please contact Caroline Newnham.

Host: Eric Miska

DNA methylation-based control of transposons is absolutely essential for the production of spermatozoa in mammals. In the mouse, this function is dependent upon the newly discovered DNMT3C DNA methyltransferase, which has specifically evolved by tandem duplication of the DNMT3B gene some 40 million years ago in the Muroidea lineagee. DNMT3C has the ability to selectively methylate the promoters of the most active transposons and only in the context of fetal spermatogenesis. As a key to understand the basis of such specialization, we will discuss our latest insights into the evolution of DNMT3C and the dynamics of de novo methylation of young transposons sequences during male germ cell development.

This talk is part of the Genetics Seminar series.

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