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Seminars on Quantitative Biology @ CRUK Cambridge Institute
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This seminar series offers a forum to present quantitative approaches to cancer research and biology, including genomics and imaging. If you want to be sent updates on talks please
If you have any other queries about this seminar series please contact Florian Markowetz. If you have a question about this list, please contact: Florian Markowetz; Kate Davenport; pau.creixell; ; sv531. If you have a question about a specific talk, click on that talk to find its organiser. 5 upcoming talks and 169 talks in the archive. Steering the evolutionary dynamics of cancer through space and time
The Roles of the Epilepsy-Associated Kinase CDKL5
How to Fold Every Protein: (Mission Accomplished?)
Protein Evolution in Sequence Landscapes - From Data to Models and Back
Protein genetic architecture is simple, and epistasis can facilitate the evolution of new functions
Quantitative Biology Seminar**Seminar cancelled**
Digital Cancer Twins: From Mechanistic Insights to Therapeutic Applications
Programmed evolution: Using asexual gene drives to sculpt tumor populations and combat genetic diversity
Screening Approaches for the Identification of Covalent Peptide Inhibitors
Cell size - A new hallmark of aging?
Functional studies of genetic variation using precision genome editing
Exploring cell heterogeneity in health and disease using single-cell proteomics and transcriptomics
Studying human oncoproteins beyond cancer: lessons learned from the RAS GTPases
OpenFold: Lessons learned and insights gained from rebuilding and retraining AlphaFold2.On Zoom Only
Oncogene-like addiction to aneuploidy in human cancers
Mammalian Synthetic Biology – Biomolecular Circuits as Medicine
Mapping somatic evolution with single-cell multi-omics
Interpretable Neural Networks for Computer Vision: Clinical Decisions that are Computer-Aided, not Automated
On the Evolutionary History of Metastatic Cancer
Combining multi-omics and biological knowledge to extract disease mechanismsPlease contact Ciara for further details
Deciphering Shared Intratumor Transcriptional Heterogeneity of Human Tumors
The Genomic Evolution of Cancer
Drug response and tolerance in normal and cancer cells
Causality, Perturbations, Gene Regulation, and Drug Repurposing
Accelerating drug discovery with the power of microscopy & AI
Genomic and digital pathology approaches to elucidate cancer dormancyHybrid seminar, please join at: https://zoom.us/j/97592722368?pwd=eXg4bHN3SEJKMm5hRXpCZUtncnVBdz09
MAGNATM, a novel single molecule platform to analyze genetic variation and epigenetic modifications on native RNA and DNA molecules
Artificial intelligence for prediction of genetic alterations directly from histology imagesPlease email tania.smith@cruk.cam.ac.uk to request the Zoom registration link
Engineering model-based systems to monitor and steer subclonal dynamics
Determining the age of Barrett’s esophagus using stochastic multiscale modeling and epigenetic clocks
Visualizing Spatial Single-Cell Data with VitesscePlease email anna.toporska@cruk.cam.ac.uk by Friday 5th February to receive a ZOOM registration link
Deep learning in medical imaging - successes, pitfalls and challengesPlease email anna.toporska@cruk.cam.ac.uk by Friday 11th December to receive a ZOOM registration link
Computational analysis of cancer genomesPlease email anna.toporska@cruk.cam.ac.uk by Friday 6th November to receive a ZOOM registration link
Cancer Genetics Through the Lens of Mutational Signatures and the Two-Hit Hypothesis.Please email anna.toporska@cruk.cam.ac.uk by Friday 16th October to receive a ZOOM registration link
Characterizing and forecasting tumour evolutionPlease email anna.toporska@cruk.cam.ac.uk by Friday 25 September to receive a ZOOM registration link
Understanding regulatory systems and mechanisms of genetic interactions: from yeast to pediatric cancerPlease email anna.toporska@cruk.cam.ac.uk to receive a ZOOM registration link
Statistical challenges posed by heterogeneous data from immunology and microbiologyPlease email anna.toporska@cruk.cam.ac.uk by Friday 12th June to receive a ZOOM registration link
“Focus on the Individual; The importance of chromosome-specific biology in generating aneuploidy patterns in cancer”Please email anna.toporska@cruk.cam.ac.uk to receive a ZOOM registration link
CANCELLED
CANCELLED
Statistical challenges posed by heterogeneous data from immunology and microbiology- CANCELLED
Visual Exploration of Longitudinal Oncology Data - CANCELLED
Dissecting context dependent cancer signalling processes using CRISPR-based approaches
Image-based quantitative morphology with geometrical models
A systems biology approach to identify perturbed processes driving cancer
Regulatory Genomics: From Basic Biology to Disease Mechanisms and Ageing
Learning Engines for Healthcare: Using Machine Learning to Transform Clinical Practice and Discovery
Cell-of-origin of prostate cancer and clinical heterogeneity
Non invasive detection of tissue specific cell death via methylation patterns of circulating DNA
Cancer Genome Evolution and Immune EscapeYou must email Anna.Toporska@cruk.cam.ac.uk prior to the talk if you are not based in CRUK CI and you wish to attend.
Exploring the role of ion channels in cancer using executable modelling
Gone fishing. Machine-learning guided discovery from public data.
Dynamics of HIV Intra-Patient Drug Resistance Evolution through Space and Time
Patient-past based precision medicine: multi-morbidities in a life-course perspective
Dissecting Receptor Tyrosine Kinase Signaling Networks by Quantitative Phosphoproteomics
Enhancers as regulatory hubs in mammalian embryogenesis and human congenital diseaseAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
Inferring the Evolutionary History of Cancers: Statistical Methods and ApplicationsAll people external to CRUK CI needs to be booked as visitors. Thank you.
Mutational heterogeneity in promoter regions in melanomaAll external guests should arrive to the room at least 5 minutes before the start of the talk.
Improving Openness and Reproducibility of Scientific ResearchPlease note that this event will be recorded. Guests should arrive to the Lecture Theatre at leat 5-10 minutes prior the talk, swich off their phones and minimise disruption and noise level to the minimum. Use of wi-fi is not allowed during the talk.
To be confirmedAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
Coding and non-coding cancer mutationsAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
Statistical Bioinformatics at ScaleAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
To be confirmedAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
Building a bigger brain: genetic bases for the evolution of the human neocortexAll people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.
Functional variation in the human genome: lessons from the transcriptomeIf you have a question about this talk or would like to attend this talk but you are from outside CRUK CI, please contact Kamila.Lembrych-Turek. Please note that all external visitors have to be booked onto an internal visitors' booking system.
Alternative splicing: widespread fine-tuning regulatory process or costly errors?All external to CRUK CI people need to be booked at least 24 hours prior the talk. Please contact Kamila by email if you would like to come.
Alternative splicing: widespread fine-tuning regulatory process or costly errors?All external to CRUK CI people need to be booked at least 24 hours prior the talk. Please contact Kamila by email if you would like to come.
The blind watch-breaker: evolution at regulatory sites in cancerIf you have a question about this talk or would like to attend this talk but you are from outside CRUK CI, please contact Kamila.Lembrych-Turek. Please note that all external visitors have to be booked onto an internal visitors' booking system.
Modeling cancer evolution from genomic dataPlease note that all external visitors have to be booked onto an internal visitors' booking system.
Title to be confirmedIf you have a question about this talk or would like to attend this talk but you are from outside CRUK CI, please contact Kamila.Lembrych-Turek. Please note that all external visitors have to be booked onto an internal visitors' booking system.
Transposable elements and epigenome evolutionIf you have a question about this talk or would like to attend this talk but you are from outside CRUK CI, please contact Kamila.Lembrych-Turek. Please note that all external visitors have to be booked onto an internal visitors' booking system.
Evolution, genomics and mode of action of long noncoding RNAs in mammalian cellsIf you have a question about this talk, please contact Kamila.Lembrych-Turek from CRUK CI.
The Long-legged mouse and the Impossible Hybrid – the genetics of genome evolution in the mouse from stem cells to whole organismsIf you have a question about this talk, please contact Kamila.Lembrych-Turek.
Non-coding genome function in pancreatic islets and diabetesIf you have a question about this talk, please contact Kamila.Lembrych-Turek.
A Bayesian ordination method for 16S microbiome profiling data
Decision making in hierarchical multi-label classification (HMC) problems
Sex chromosomes in development and disease
Gene-drug interaction screens in cancer
Adventures in structural variation and evolution in cancer
Mining the root causes, driver mutations snd therapeutic opportunities from recalcitrant cancers
Title to be confirmedCANCELED
Discovering enhancer sequences with a role in vertebrate left-right patterning
A Horizontal Transfer from Bacteria to Fungi Enhances Fungal Pathogenicity
Title to be confirmed
Reconstructing the evolutionary history of tumours
Whole-genome sequencing of cell-free DNA in maternal plasma
Targeting the brain tumour stem cell phenotype with small molecules
Dissecting translation efficiency through lab evolution, genome engineering and inspection of the cancerous genome
Modelling the transcriptional response to ER signalling in breast cancer cells
Discovery and allele frequency estimation of somatic twilight zone insertions and deletions
The Cancer Genome Atlas: oncogenic signature classes and the design of combinatorial therapy
Variations in genetic and phenotypic diversity during breast cancer progression.
Single molecule approaches for studying gene expression in intact mammalian tissues.
The Resistant Cancer Cell Line (RCCL) collection – cancer cell lines with acquired drug resistance as a pre-clinical and basic science model
Using time-resolved genetic data to study the evolution of drug resistance.
Profiling the Subclonal Copy Number Architecture from Whole Genome Sequencing of Heterogeneous Tumours
Systems biology of stem cell fate
Incorporating Prior Biological Knowledge into Genetic Association Studies
Measuring within-tumour diversity as a universal biomarker for cancer prognosis
Analysis of a large cancer gene screen in myelodysplastic syndromes
Colon CSCs are sensitized by HDACinhibitors in a FOXO-dependent fashion
Platinum Genomes
Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancerNote unusual day and time!
Petri nets as semi-quantitative modeling method to explore systems behavior of disease-related pathways
Genome-wide association studies: Lessons from studying a large clinical cohort
Mapping tumor heterogeneity and developmental trajectories using 40 markers at single cell resolution:Room change: 215 instead of lecture theatre (outside guests will need visitor ID)
Inferring causal mediators from omics data in the context of genetic and environmental variations
The logic and variation in genomic regulatory networks
Metabolic regulation of the stress response and the cancer cell's Warburg effect
Evolution of cellular networks: from interactions to phenotypes
Circulating tumour DNA as a biomarker of genetics alterations in cancer
Network biology of cancer
From protein networks to disease mechanisms
Variational Methods in 3+Dimensional Biomedical Imaging
The life histories of 21 breast cancers
Biological Image Analysis Made EasyNote the unusual time: 11am not 4pm!
The evolution of mammalian tissue transcriptomes
Modeling stem cell differentiation on multiple scalesTuesday, not Monday!
Machine learning applications in genetic regulation and cancer
ShrinkSeq: a flexible and powerful method for Bayesian analysis of RNAseq dataNote the time change: 2pm (not 4pm)
Evolution of developmental gene expression programs
Modelling in systems genetics: computational approaches for discovering disease networks
Model Based Target Identification from Expression Data
The Search for Organizing Principles in Cancer Systems Biology
Increased methylation variation across cancer types
RNAi libraries for high throughput phenotyping and drug resistance screening in the African trypanosome
RNAi-based molecular computing for cancer cell detection
Inferring mechanisms of gene regulation from patterns of evolutionary divergence
Chromatin-mediated regulation of gene expression in mouse ES cells
Adult stem cell fate: a laboratory for statistical physics
Perturbation Biology of Cancer Cells
Phylogenetic Inference of Multidomain Evolution
Allele specific expression design using short read DNA sequencing and application to the genetics of autoimmune disorders
CRUK computational biology day
Do modules or pathways help predict breast cancer outcome?
From data to bench to bedside - prognostic markers and therapeutic targets in breast cancer
Evidence of non-random mutation rates suggests a risk management strategy for bacterial evolution
Intrinsically Unstructured Proteins: Regulation and Disease
Theoretical models of the development of the nervous system
Using association-based genetics to understand basic biology
Integrative Network Biology and Cellular Information Processing
The evolution and regulation of gene expression levels in mammals
Finding interesting clusters using Bayesian data fusion
Deconvolving the epigenome
Transcriptional characterization of glioma stem cells using high-throughput tag sequencing
Evolutionary Signatures of Strand Specific Mutagenic Processes
Unexpected complex dynamics of cellular transcriptional response
Uncovering signaling differences between normal and transformed hepatocytes using cell-specific pathway models
Accelerated substitution rates in non-coding sequence: Gene duplication, transcription factor binding site turnover and biased gene conversion.
A quantitative view of gene expression levels and epigenetic modifications
ChIP-Seq in six Drosophila species reveals a highly similar binding landscape for the developmental transcription factor Twist.
Dynamics of molecular clocks expose the lineage relations of cells
Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
A global map of human gene expression
Title to be confirmed
Learning the structure of graphical models with latent variables
Next generation computing for next generation sequencing
Analysing the pharmacokinetics and pharmacodynamics of drugs in vivo by upgrading in vitro data based on mathematical modelling
New Approaches to Biomedical Data Modelling: An Introductory Tutorial
Biochemical network reconstruction from data
Cancer Tumour/Normal Pair Analysis with the Illumina Genome Analyzer
Towards a transcriptional taxonomy of in vitro stem cell preparations
The Executable Pathway to Biological Networks
The Code Underlying Tissue-Regulated Splicing
Please see above for contact details for this list. |
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Jeffrey West, Ph.D. Assistant Member, Integrated Mathematical Oncology H. Lee Moffitt Cancer Center & Research Institute.
Monday 03 February 2025, 12:30-13:30