Inferring mechanisms of gene regulation from patterns of evolutionary divergence

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• Itay Tirosh (Weizmann Institute)
• Wednesday 26 October 2011, 16:00-17:00
• Cancer Research UK Cambridge Research Institute, Room 215.

If you have a question about this talk, please contact Florian Markowetz.

Evolution of gene expression plays a major role in generating phenotypic diversity and has been studied extensively in recent years. I will present a comprehensive comparative analysis of gene regulation between yeast species and the emerging evolutionary insights. Importantly, apart from understanding the evolutionary process, these analyses reveal the dynamics of gene expression and thereby elucidate basic mechanisms and principles of gene regulation. I will highlight a hybrid-based approach that is instrumental in these analyses, and describe the coupling that we recently identified with this approach between transcription and mRNA degradation.

Note the date and room change: Wednesday in 215

Hosted by Nitzan Rosenfeld

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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