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The Search for Organizing Principles in Cancer Systems Biology

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If you have a question about this talk, please contact Florian Markowetz.

Cancer systems biology is an approach by which cancer-related cell-biological questions are addressed through iterative cycles of data-driven modelling and model-driven experimentation. In my presentation I shall review and point out limitations in the current practice of pathway-centric mechanistic modeling. This leads me to a new perspective that integrates levels of structural and functional organization: from the molecular/cell level to the tissue level, from network models to multilevel systems, from studying mechanisms to identifying organizing principles. Organizing principles in systems biology are robust generalizations, akin to natural laws in physics or chemistry. I argue that the search for organizing principles requires novel approaches and I shall give examples for the direction in which these new developments should go.

www.sbi.uni-rostock.de

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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