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Enhancers as regulatory hubs in mammalian embryogenesis and human congenital disease

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If you have a question about this talk, please contact Kamila.Lembrych-Turek.

All people external to CRUK CI needs to be booked as visitors. Please contact Kamila at least 24 hours prior the talk.Thank you.

The establishment of cell type-specific gene expression programs largely depends on a group of distal cis-regulatory elements broadly referred to as enhancers. By serving as binding platforms for transcription factors, enhancers can integrate signalling and epigenetic cues in order to exquisitely control the expression of their target genes. Furthermore, accumulating evidences suggest that changes in the regulatory activity or topology of enhancer landscapes due to genetic or structural variation, respectively, can represent a major cause of human disease. During my talk I will show how, by functionally and mechanistically characterizing developmental enhancers, my laboratory aims at (i) uncovering transcriptional regulatory principles orchestrating mammalian embryogenesis and (ii) elucidating the genetic and epigenetic basis of human congenital diseases.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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