MAGNATM, a novel single molecule platform to analyze genetic variation and epigenetic modifications on native RNA and DNA molecules

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• Dr Jimmy Ouellet, Depixus SAS
• Tuesday 16 November 2021, 10:00-11:00
• CRUK CI Room 009/009A.

If you have a question about this talk, please contact June Rix.

Over the last decade, it has become clear that analysis of multiple features on the same molecule using the same platform have an enormous advantage over combining multiple experiments done on different platforms. Depixus® is developing a single molecule platform based on magnetic tweezer technology that will allow both genetic analysis of nucleic acid (either RNA or DNA ) as well as their potential epigenetic modification on a single platform at single base resolution. One of the strengths of the platform is the non-destructive nature of the analysis, which allows the repeated probing of the substrate with various blocking agents to extract the desired information and increase the confidence in the event detected. Moreover, the versatility of the platform allows analysis of molecules from a few bases up to kilobases, which opens new avenues to analyze a broad range of native nucleic acid molecules.

We will be presenting our latest results on the detection of different base modifications on DNA and RNA with great sensitivity (>95%) as well as specificity. Moreover, using our newly developed enrichment strategy, we have been able to fully demonstrate the power of both genetic and epigenetic analysis by measuring repeat length of the fragile X syndrome gene (FmrI) as well as methylation status of the CpG island located in its 5’ UTR on the same molecule in healthy versus affected individuals. We believe that the MAGNATM platform will allow researchers to simplify analysis of native nucleic acids, opening new insights into the dynamic genome.

External visitors to the CRUK CI please register using the link below

https://www.eventbrite.co.uk/e/seminars-on-quantitative-biology-cruk-ci-dr-jimmy-ouellet-depixus-sas-tickets-208665252387

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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