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Sex chromosomes in development and disease

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If you have a question about this talk, please contact Florian Markowetz.

Males and females differ fundamentally in their sex chromosome make-up: females have two X chromosomes (XX), while males have one X chromosome and one Y chromosome (XY). The sex chromosomes have a predominant role in the formation of germ cells, but also influence male-female differences in growth, behaviour and susceptibility to a variety of diseases, e.g. hypertension and cancer. Furthermore, the imbalance in dosage for X genes between females and males presents unique challenges for the developing embryo that are overcome by X chromosome inactivation – the silencing of one X chromosome in each female cell.

Our lab studies the epigenetics, evolution and cell biology of the sex chromosomes from a variety of organisms, including mammals, in order to understand how these chromosomes influence human health and disease.

I will describe our recent findings relating to these diverse aspects of sex chromosome biology.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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