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Cancer Genome Evolution and Immune Escape

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Lung cancer is the leading cause of cancer-related mortality worldwide. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lung adenocarcinomas (LUAD) and lung squamous cell carcinomas (LUSC). However, in-depth exploration of NSCLC intra-tumour heterogeneity and cancer genome evolution has been limited to small retrospective cohorts. As such, the clinical significance of ITH , the potential for clonality of driver events to guide therapeutic strategies is not yet defined, and the interplay between the cancer cell and the immune system remains poorly understood. In his talk Dr Nicholas McI will outline how intra-tumour heterogeneity can be deciphered using multi-region sequencing. He will examine how heterogeneity can be utilized to gain a deeper understanding of tumour evolution, focusing on the importance of large scale copy number alterations, including whole-genome doublings and mutational process generating heterogeneity. He will also explore the interaction between cancer genome evolution and anti-tumour immunity and mechanisms of immune escape.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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