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Gene-drug interaction screens in cancer

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If you have a question about this talk, please contact Florian Markowetz.

With the complete molecular characterization of the major cancer types in sight, it is clear that only a minority of the cancer genes represent readily accessible drug targets. Furthermore, mechanistic biomarkers that predict response to targeted therapies remain scant. We employ large-scale chemical genetic screens in isogenic cells to systematically uncover gene-drug interactions in cancer. In this seminar, I will present recently published and unpublished work uncovering unexpected gene-drug interactions with potential clinical relevance. I will also present our recent efforts to employ systematic reverse genetic screens using high throughput RNA -seq in arrayed collections of CRISPR /Cas9 edited cell lines.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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