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Mutational heterogeneity in promoter regions in melanoma

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Sequencing of whole tumor genomes holds the promise of revealing recurrent mutations in non-coding DNA , as described in the TERT promoter. However, proper interpretation of such patterns requires an understanding of how mutations arise and distribute across the genome in the absence of selective pressures. In this seminar I will discuss heterogenous patterns of UV-induced somatic mutations in skin cancers, where recurrent promoter mutations are common but where these appear to be explainable to a large extent by highly localized elevations in mutation rate.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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