University of Cambridge > Talks.cam > Seminars on Quantitative Biology @ CRUK Cambridge Institute  > Adult stem cell fate: a laboratory for statistical physics

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Adult stem cell fate: a laboratory for statistical physics

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Florian Markowetz.

In adult, tissues are maintained and repaired by stem cells, which divide and differentiate to generate more specialized progeny. The mechanisms that control the balance between proliferation and differentiation promise fundamental insights into the origin and design of multi-cellular organisms. However, stem cells are usually difficult to distinguish from their more differentiated progeny, and resolving these mechanisms has proved challenging. Combining the results of inducible genetic labeling studies from a range of tissue types with concepts from population dynamics and statistical physics, we show how scaling behaviour of clone size distributions reveals signatures of stochastic stem cell fate. As well as providing insight into the molecular regulatory mechanisms controlling the maintenance, repair and regeneration of adult tissues, these results provide a platform to explore pathways of dysregulation and tumorigenesis.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Numerical Analysis DAMTP Friday GR Seminar Global Intellctual History

Other talks

Constructing the virtual fundamental cycle Structurally unravelling ATP synthase Childhood adversity and chronic disease: risks, mechanisms and resilience How to Design a 21st Century Economy - with Kate Raworth Behavioural phenotypes of children born preterm: what we know and future research avenues Title to be confirmed Retinal mechanisms of non-image-forming vision Direct measurements of dynamic granular compaction at the mesoscale using synchrotron X-ray radiography An SU(3) variant of instanton homology for webs Cyclic Peptides: Building Blocks for Supramolecular Designs Throwing light on organocatalysis: new opportunities in enantioselective synthesis The Hopkins Lecture 2018 - mTOR and Lysosomes in Growth Control
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity