Bayesian inference of genetic epistasis in case-control studies

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• Professor Jun Liu (Harvard)
• Tuesday 04 March 2008, 17:00-18:00
• Wolfson Room (MR 2) Centre for Mathematical Sciences, Wilberforce Road, Cambridge.

If you have a question about this talk, please contact Helen Innes.

I will discuss a Bayesian approach to detect multi-locus interactions (Epistasis) for both case-control association studies and an un-supervised scenario. Existing methods are either of low power or computationally infeasible when facing a large number of genetic markers, and sometimes also many quantitative traits. Aided with MCMC sampling techniques, our Bayesian method can efficiently detect interactions among many thousands of markers. This method can be generalized to deal with classification problems. I will also discuss the issue of statistical significance in this situation.

This talk is part of the Kuwait Foundation Lectures series.

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