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On the biophysics of cilia polarity

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The establishment of motile cilia orientation (cilia polarity) during embryonic development is orchestrated by mechanical forces. However, the actual nature of these forces and their transduction remain unknown. In order to understand this process, we consider the multi-ciliated cells (MCCs) on the Xenopus larval skin, and set-up an experiment for the live-imaging of MCCs during the application of an external flow. After discussing the basic hydrodynamics of the system, I will show preliminary results on the response of intracellular ciliary structures to the applied forces.

This talk is part of the DAMTP BioLunch series.

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