"A non-stationary Bayesian model for across-site heterogeneity in molecular phylogenetics"

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• Dr Sarah Heaps, University of Newcastle
• Tuesday 05 July 2016, 14:30-15:30
• Large Seminar Room, 1st Floor, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge.

If you have a question about this talk, please contact Alison Quenault.

Standard phylogenetic models of molecular sequence evolution assume that the evolutionary process is homogeneous across sites and stationary over time. However, these assumptions are known to be biologically untenable and the implied sequence properties are discordant with those of many real data sets. We describe a non-stationary model which allows heterogeneity in the patterns of substitution across sites through a site-specific quadratic transformation of a baseline rate matrix. This generalises the commonly applied approach of allowing site-specific scaling of an underlying rate matrix.

This talk is part of the MRC Biostatistics Unit Seminars series.

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