Discovering the gene networks that regulate hunger

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• Katherine Lawler, Research Associate Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital
• Wednesday 08 March 2023, 14:00-15:00
• CMS, Meeting Room 15.

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ABSTRACT for 8th Mar 2023, https://talks.cam.ac.uk/show/index/134146

Title: Discovering the gene networks that regulate hunger Studying a rare disease with extreme clinical features can lead to new treatments for patients, and uncover underlying mechanisms involved in common disorders and population health. The Genetics of Obesity Study (GOOS, http://www.goos.org.uk ) recruited thousands of individuals with severe early-onset childhood obesity and led to the identification of rare genetic variants affecting key processes in the hypothalamus, a part of the brain involved in appetite, weight regulation and energy balance. To gain further insights our current work encompasses the genetics of rare severe childhood obesity and the genetics of thinness. We combine large genomic data sets from different populations and platforms with detailed clinical information to discover new molecular pathways involved in appetite, weight regulation and associated disorders.

This talk is part of the Computational and Systems Biology Seminar Series 2023 - 24 series.

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